نتایج جستجو برای: پروتئین abcg2

تعداد نتایج: 20375  

Journal: :Blood 2006
Niove E Jordanides Heather G Jorgensen Tessa L Holyoake Joanne C Mountford

Imatinib mesylate (IM) therapy for chronic myeloid leukemia (CML) has transformed the treatment of this disease. However, the vast majority of patients, despite major responses, still harbor Philadelphia chromosome-positive (Ph(+)) cells. We have described a population of primitive Ph(+) cells that are insensitive to IM and may be a source of IM resistance. Cell line studies have suggested that...

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Journal: :Food chemistry 2013
Kee W Tan Yan Li James W Paxton Nigel P Birch Arjan Scheepens

Breast cancer resistance protein (BCRP/ABCG2) plays an important role in determining the absorption and disposition of consumed xenobiotics including various drugs and dietary phytochemicals and is also one of the prominent efflux transporters involved in multidrug resistance (MDR). In this study, we have investigated the interactions between ABCG2 and 56 naturally-occurring phytochemicals incl...

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Journal: :Anticancer research 2004
Petra Kowalski Kate M Farley Hermann Lage Erasmus Schneider

BACKGROUND Ribozymes are an effective tool to reduce the mRNA levels of specific target genes. Overexpression of the drug transport protein, ABCG2, has been associated with multidrug resistance in cancer cells. MATERIALS AND METHODS An expression plasmid encoding a hammerhead ribozyme against the ABCG2 gene was stably transfected into multidrug-resistant MCF7/MX cells that express very high l...

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2013
Hirotaka Matsuo Kimiyoshi Ichida Tappei Takada Akiyoshi Nakayama Hiroshi Nakashima Takahiro Nakamura Yusuke Kawamura Yuzo Takada Ken Yamamoto Hiroki Inoue Yuji Oikawa Mariko Naito Asahi Hishida Kenji Wakai Chisa Okada Seiko Shimizu Masayuki Sakiyama Toshinori Chiba Hiraku Ogata Kazuki Niwa Makoto Hosoyamada Atsuyoshi Mori Nobuyuki Hamajima Hiroshi Suzuki Yoshikatsu Kanai Yutaka Sakurai Tatsuo Hosoya Toru Shimizu Nariyoshi Shinomiya

Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset age data and 1,887 male controls were genotyped, and the ABCG2 functions which a...

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2011
Lei Xiang Peng Su Shujun Xia Zhiyan Liu Yan Wang Peng Gao Genyin Zhou

BACKGROUND ABCG2 is an ABC transporter. It has been demonstrated that endogenous ABCG2 expression in certain cancers is a possible reflection of the differentiated phenotype of the cell of origin and likely contributes to intrinsic drug resistance. But little is known about the contribution of ABCG2 to the drug resistance and the clinicopathological characteristics in breast cancer. In the pres...

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Journal: :Acta medica Okayama 2013
Masanao Yamamoto Hirofumi Fujita Naoki Katase Keiji Inoue Hitoshi Nagatsuka Kozo Utsumi Junzo Sasaki Hideyo Ohuchi

Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassett...

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Journal: :Drug metabolism and disposition: the biological fate of chemicals 2012
Lipeng Wang Markos Leggas Philip E Empey Patrick J McNamara

(-)Pantoprazole [(-)PAN] accumulated in rat milk stereoselectively, and this accumulation was attributed to rat Abcg2 (rAbcg2). In contrast, flux experiments at 25 μM showed that (+)pantoprazole [(+)PAN] was preferentially transported by rAbcg2. The purpose of the current study was to comprehensively evaluate the transport of PAN isomers in empty-Madin-Darby canine kidney II (MDCKII) and MDCKII...

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Journal: :Cancer research 2007
Kazumasa Takenaka Jessica A Morgan George L Scheffer Masashi Adachi Clinton F Stewart Daxi Sun Markos Leggas Karin F K Ejendal Christine A Hrycyna John D Schuetz

The use of probe substrates and combinations of ATP-binding cassette (ABC) transporter knockout (KO) animals may facilitate the identification of common substrates between apparently unrelated ABC transporters. An unexpectedly low concentration of the purine nucleotide analogue, 9-(2-(phosphonomethoxy)ethyl)-adenine (PMEA), and up-regulation of Abcg2 in some tissues of the Mrp4 KO mouse prompte...

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Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Fatemeh Kalalinia Fatemeh Elahian Mitra Hassani Jamal Kasaeeian Javad Behravan

Recent studies have indicated a link between levels of cyclooxygenase-2 (COX-2) and development of the multidrug resistance (MDR) phenotype. The ATP-binding cassette sub-family G member 2 (ABCG2) is a major MDR-related transporter protein that is frequently overexpressed in cancer patients. In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression usin...

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Journal: :The Biochemical journal 2013
Ágnes Telbisz Csilla Özvegy-Laczka Tamás Hegedűs András Váradi Balázs Sarkadi

The human ABCG2 multidrug transporter actively extrudes a wide range of hydrophobic drugs and xenobiotics recognized by the transporter in the membrane phase. In order to examine the molecular nature of the transporter and its effects on the lipid environment, we have established an efficient protocol for the purification and reconstitution of the functional protein. We found that the drug-stim...

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