OBJECTIVE To determine whether immediate initiation of treatment at the time of a clinically isolated syndrome in patients at high risk for clinically definite multiple sclerosis alters disease course over 10 years. DESIGN Prospective follow-up study. SETTING Twenty-four Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study (CHAMPS) sites in the United States and Canada. ...

INTRODUCTION The Rapid Assessment of Physical Activity (RAPA) was developed to provide an easily administered and interpreted means of assessing levels of physical activity among adults older than 50 years. METHODS A systematic review of the literature, a survey of geriatricians, focus groups, and cognitive debriefings with older adults were conducted, and an expert panel was convened. From t...

A new message-passing scheme for MRF optimization is proposed in this paper. This scheme inherits better theoretical properties than all other state-of-the-art message passing methods and in practice performs equally well/outperforms them. It is based on the very powerful technique of Dual Decomposition [1] and leads to an elegant and general framework for understanding/designing message-passin...

This paper is motivated by operating self service transport systems that flourish nowadays. In cities where such systems have been set up with bikes, trucks travel to maintain a suitable number of bikes per station. It is natural to study a version of the C-delivery TSP defined by Chalasani and Motwani in which, unlike their definition, C is part of the input: each vertex v of a graph G = (V,E)...