Triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer, shows higher metastases and relapse rates than other subtypes. The metastasis of TNBC is the main reason for the death of TNBC patients. Increasing evidence has shown that inhibiting the metastasis of TNBC is a good method for TNBC treatment. Here, VSP-17 was designed and synthesized as an agonist of PPARγ, evidenced ...

In Escherichia coli, T:G mismatches in specific contexts are corrected by a very short patch (VSP) repair system. Previous studies have shown that the product of gene vsr mediates correction of T:G to C:G in the 5'CTAGG/3'GGTCC context and in some related contexts. Amber mutations that arose in CAG sequences in gene cI of bacteriophage lambda were used to determine the effect of flanking bases ...

Environmental characterization is necessary to support remediation and monitoring decisions and to construct and validate contaminant dispersion models. The more samples obtained, the greater is the protection against making incorrect decisions. However, taking too many samples wastes valuable resources. The US Environmental Protection Agency has developed several guidance documents on the Data...

In this paper we provide an evaluation and certification approach for Voting Service Providers (VSPs) which combines the evaluation of the electronic voting system and the operational environment for the first time. The VSP is a qualified institution which combines a secure voting system and a secure operational environment to provide secure remote electronic elections as a service [La08]. This...

BACKGROUND Orthognathic surgery has traditionally been performed using stone model surgery. This involves translating desired clinical movements of the maxilla and mandible into stone models that are then cut and repositioned into class I occlusion from which a splint is generated. Model surgery is an accurate and reproducible method of surgical correction of the dentofacial skeleton in cleft a...

Perspective-taking is a key component of social interactions. However, there is an ongoing controversy about whether, when and how instances of spontaneous visuospatial perspective-taking occur. The aim of this study was to investigate the underlying factors as well as boundary conditions that characterize the spontaneous adoption of another person’s visuospatial perspective (VSP) during social...

E. coli genes that contain a high frequency of the tetranucleotide CTAG are also rich in the tetramers CTTG, CCTA, CCAA, TTGG, TAGG, and CAAG (group-I tetramers). Conversely, E. coli genes lacking CTAG are rich in the tetranucleotides CCTG, CCAG, CTGG, and CAGG (group-II tetramers). These two gene samples differ also in codon usage, amino acid composition, frequency of Dcm sites, and contrast v...

Purpose – This paper aims to present a novel feature design that is able to precisely describe salient objects in images. With the development of space survey, sensor and information acquisition technologies, more complex objects appear in high-resolution remote sensing images. Traditional visual features are no longer precise enough to describe the images. Design/methodology/approach – A novel...

The ability to produce from low permeability, tight gas reservoirs is directly tied to the ability to repetitively perform successful hydraulic fracturing in a series of closely spaced wells. The key question is whether the induced fractures remain open and permeable, which is in part a function of the stress field and the emplacement of proppant. We study the ability to detect and characterize...

BACKGROUND Most ion channels are regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) in the cell membrane by diverse mechanisms. Important molecular tools to study ion channel regulation by PtdIns(4,5)P(2) in living cells have been developed in the past. These include fluorescent PH-domains as sensors for Förster resonance energy transfer (FRET), to monitor changes in plasma me...