C57BL/6 (B6) mice carrying the Sle1b sublocus (named B6.Sle1b), which harbors the lupus-associated NZM2410/NZW SLAM family genes, produce antinuclear Abs (ANAs). However, the role and mechanism(s) involved in the alteration of the germinal center (GC) tolerance checkpoint in the development of ANAs in these mice is not defined. In this study, we show significantly higher spontaneously formed GC...

Pathology due to the immune system's response to viral infections often represents a delicate balance between inhibition of viral pathogenesis and regulation of protective immunity. In susceptible C57BL/6 (B6) mice, the murine retroviral isolate LP-BM5 induces splenomegaly, hypergammaglobulinemia, profound B- and T-cell immunodeficiency, and increased susceptibility to opportunistic pathogens a...

BACKGROUND Vitamin B6 may directly or indirectly play a role in oxidative stress and the antioxidant defense system. OBJECTIVE The purpose of this study was to examine the associations of vitamin B6 status with cysteine, glutathione, and its related enzyme activities in mice with homocysteine-induced oxidative stress. DESIGN Four-week-old male BALB/c mice were weighed and divided into one o...

Usp46 mutant mice (congenic strain on a B6 genetic background; MT mice) have a low weaning rate and display poor maternal behavior compared to C57BL/6J mice (B6 mice). Based on these observations, we examined how maternal behavior is shaped by cross-fostering and in-fostering MT and B6 mice. The experiments consisted of six groups: B6 mice fostered by their biological mother (B6-CO); MT mice fo...

PURPOSE To determine the extent to which CD95 ligand (CD95L) expressed on corneal epithelium and endothelium influences survival of cornea grafts placed orthotopically and heterotopically in the anterior chamber (AC), an immune-privileged site. METHODS Corneas from eyes of C57BL/6 (B6) and B6.gld (CD95L deficient) mice were (1) rendered into small full-thickness fragments, with or without an ...

The H-2Dd transgenic strain D8 on C57BL background was more resistant to subcutaneous challenge of RBL-5 lymphoma cells than B6 controls. The direct role of the H-2Dd antigen was investigated by the use of (D8 x B6)F1 crosses and (D8 B6) x B6 backcrosses. The latter showed cosegregation with regard to Dd antigen expression and lymphoma resistance, both of which were inherited in a pattern consi...

It has been shown that 4-desoxypyridoxine (1, 2), incites seizures (3) and vita min B6-deficient states (3-6) in animals, but INAH (1) also has the property of inducing running fits (7, 8, 9) and vitamin B6 deficiency (10-13) and of inhibiting the enzymes related to vitamin B6 (14-20). The results of Makino and Aramaki (21-25), Kooka (26) and Miyake (27) show that 2-methyl-4-amino5-hydroxymethy...

a bstra ct   background: nausea and vomiing are the common symptoms of early pregnancy. without treatment, vomiting can complicate the pregnancy, so it must be reduced. wide varieties of treatment have been used for nausea and vomiting in pregnancy. this study compared the effectiveness of vitamin b6 and dimenhydrinate for gestational nausea and vomiting.     materials and methods: one hundred ...