نتایج جستجو برای: واژگان کلیدی خطبه 219
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صدیقه طاهره (س) اولین کسی بودند که بعد از رحلت پیامبر اکرم (ص) به مبارزه با انحرافات پیش آمده، پرداختند و اصل "تداوم نظارت امامان معصوم بر اصالت دین" را تحقق بخشیدند؛ نمونه ای از تلاش های بزرگ بانوی اسلام (س) در این مبارزه، ایراد خطبه های غرا و آتشین و از آن جمله، خطبه فدک است. یکی از ابعاد مهم این خطبه و شاید مهمترین بعد آن، حضور قرآن است؛ پیدایش و حضور این بعد، رهاورد پیوند ویژه آن حضرت با قر...
Dysregulated expression of miR-219, a brain-specific microRNA, has been observed in neurodevelopmental disorders, such as schizophrenia (SCZ). However, its role in normal mammalian neural stem cells (NSCs) and in SCZ pathogenesis remains unknown. We show here that the nuclear receptor TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppres...
Asymmetric self-renewing division of neural precursors is essential for brain development. Partitioning-defective (Par) proteins promote self-renewal, and their asymmetric distribution provides a mechanism for asymmetric division. Near the end of neural development, most asymmetric division ends and precursors differentiate. This correlates with Par protein disappearance, but mechanisms that ca...
Keywords are the main focal points of interest within a text, which intends to represent the principal concepts outlined in the document. Determining the keywords using traditional methods is a time consuming process and requires specialized knowledge of the subject. For the purposes of indexing the vast expanse of electronic documents, it is important to automate the keyword extraction task. S...
This paper proposes a model for the structure and content of a university World Wide Web site, by a process of: (1) identifying who the site is serving and the information needs of these individuals or groups; (2) identifying institutional information needs; (3) relating this data to the content provided; (4) presenting the content in a manner suited to the characteristics and information needs...
Malignant melanoma is a very dangerous tumor which is resistant to conventional therapy. MicroRNA exerts a vital function in promoting or inhibiting tumor development. The research has investigated the expression and function of miR-219-5p in melanoma. As a result, miR-219-5p expression was distinctly reduced in melanoma tissues and cell lines and was negatively correlated with Bcl-2 protein le...
BACKGROUND Increasing evidence suggests that microRNAs are functionally involved in the initiation and maintenance of pain hypersensitivity, including chronic morphine analgesic tolerance, through the posttranscriptional regulation of pain-related genes. We have previously demonstrated that miR-219 regulates inflammatory pain in the spinal cord by targeting calcium/calmodulin-dependent protein ...
BACKGROUND AIMS Gastric cancer is the most frequent gastrointestinal tumor in adults and is the most lethal form of human cancer. Despite of the improvements in treatments, the underlying mechanism of gastric carcinogenesis is not well known. To define novel modulators that regulate susceptibility to tumorgenesis, we focused on miR-219-2-3p. METHODS Quantitative RT-PCR was employed to investi...
Glioblastoma is one of the common types of primary brain tumors with a median survival of 12-15 months. The receptor tyrosine kinase (RTK) pathway is known to be deregulated in 88% of the patients with glioblastoma. 45% of GBM patients show amplifications and activating mutations in EGFR gene leading to the upregulation of the pathway. In the present study, we demonstrate that a brain specific ...
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