Here, we report a 28-year-old woman who transiently showed lactate dehydrogenase (LDH)-linked immunoglobulin during postpartum thyroiditis. She demonstrated high levels of serum LDH (794 IU/l) and thyroid hormones 7 months after delivery. Electrophoretic isoenzyme analysis of LDH showed an abnormal broadband caused by LDH-linked immunoglobulin (IgG-kappa). Transient thyrotoxicosis due to postpa...

Upregulation of lactate dehydrogenase A (LDH-A) is commonly observed in many tumor types. Previous studies have revealed LDH-A transcriptional activation by the increased activity of Myc and HIF in human cancers. Is LDH-A regulated by post-translational modifications during tumorigenesis? If so, can such knowledge be used to assist cancer early diagnosis and treatment? Reprogramming of energy m...

A considerable increase in LDH activity was demonstrated in the urine of children suffering from acute glomerulonephritis. The LDH isoenzyme distribution was also found to be different, compared to the normal. During recovery from the disease the pathologic LDH values returned gradually to normal. Owing to the similarity of the isoenzyme patterns, the study of the urinary. LDH and its isoenzyme...

Using Affigel Blue and oxamate-agarose affinity chromatography, lactate dehydrogenase (LDH) was purified 2000-fold from hypoxically induced barley roots. Molecular weights of the native and sodium dodecyl sulfate-denatured LDH protein were 157 and 40 kilodaltons, respectively, indicating a tetramer. Purified barley LDH was very similar in size and kinetic properties to potato LDH. However, thei...

The dentin was removed from bovine tooth germs, followed by the separation of the extracellular matrix vesicle fraction after collagenase treatment. Lactate dehydrogenase (LDH)-containing vesicles with a density different from that of matrix vesicles were detected in the matrix vesicle fraction. LDH in these vesicles did not result from cell lysis and vesicle capture during the preparation of t...

In previous communications (4, 5) we have reported that in animals with carcinoma, whether induced, transplanted, or spontaneous, there was an increase in serum lactic dehydrogenase (LDH) activity. A direct relationship was also demonstrated between LDH activity and tumor growth and regression. As the tumor grew, the LDH activity was progressively elevated, and, as the tumor regressed, LDH acti...