MicroRNAs (miRNAs) play a critical role in drug resistance and epithelial-mesenchymal transition (EMT). The aims of this study were to explore the potential role of miR-206 in governing cisplatin resistance and EMT in lung cancer cells. We found that both lung adenocarcinoma A549 cisplatin-resistant cells (A549/DDP) and H1299 cisplatin-resistant cells (H1299/DDP) acquired mesenchymal features a...

miR-206 plays an important role in regulating the growth of multiple cancer cells. Cyclin-dependent kinase 9 (CDK9) stimulates the production of abundant prosurvival proteins, leading to impaired apoptosis of cancer cells. However, it is unknown whether CDK9 is involved in the miR-206-mediated growth suppression of hepatocellular carcinoma (HCC) cells. In this study, we found that the expressio...

UNLABELLED BACKGROUND Enhancing CPG acceptance and implementation can play a major role in the development and establishment of emergency medicine as a specialty in many parts of the world. A Guideline International Network special interest group established to support collaboration to improve uptake of clinical practice guidelines (CPGs) across the emergency care sector conducted an interna...

It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated the frequency of Th17 cells and the expression of microRNA-206 (miR-206) in DM patients. Firstly, we observed that the frequency of Th17 cells and the expression of transcription factors were increased significantly in the PBMCs of DM patients. Secon...

Lead isotope ratios are widely used to identify original sources of Pb in the environment. Such source apportionment depends on the ability to distinguish potential sources on the basis of their isotopic composition. However, almost all terrestrial Pb is co-linear in some of the plots i.e. (206)Pb/(208)Pb versus (206)Pb/(207)Pb and (206)Pb/(204)Pb versus (206)Pb/(207)Pb commonly presented in th...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

MicroRNAs (miRNAs) constitute of a class small non-coding RNAs that are involved in post-transcriptional gene regulation and have important regulatory roles in many fundamental biological processes. A small number of miRNAs predominantly expressed in muscle tissue have been found to play critical role in myogenesis, muscle growth, cardiac function and muscle hypertrophy. In the present study, t...

Neuropathic pain (NP), chronic pain resulted from dysfunction or diseases of the somatosensory nervous system, is a major challenge to currently available clinical therapy of peripheral nerve injury. Although there are significant improvements in drug and surgical therapy, the efficiency of the therapeutic approach for NP is low. And the molecular mechanisms of NP maintenance are still not clea...