BACKGROUND Penetratin is a positively charged cell-penetrating peptide (CPP) that has the ability to bind negatively charged membrane components, such as glycosaminoglycans and anionic lipids. Whether this primary interaction of penetratin with these cell surface components implies that the peptide will be further internalized is not clear. METHODOLOGY Using mass spectrometry, the amount of i...

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Collagen is considered to be the principal contributor of postyield properties. Any modification of bone collagen including accumulation of non-enzymatic cross-links should, therefore, be expected to modify the fracture behavior of bone. Previous studies under monotonic loading to fracture have shown that non-enzymatic glycation (NEG) of bone reduces its post-yield properties [1,2], but no info...

Natural killer (NK) cells are critical in the first-line defense against viral infections. Chronic HIV-1 infection leads to a perturbation in the NK cell compartment, yet the kinetics of this deregulation and the functional consequences are unclear. Here, we characterized changes in the NK cell compartment longitudinally by multiparameter flow cytometry, starting in acute HIV-1 infection. Acute...

Twenty healthy volunteers (half male) recalled and relived maximally disturbing (NEG) and maximally pleasurable (POS) emotional experiences. Forty minutes of silence, then neutral conversation, preceded and followed 40 minutes of emotion elicitation (NEG and POS randomly rotated). They were under video, cardiovascular, and immunological monitoring. Subjects reported appropriate emotions and sho...

To shed light into the molecular bases of B-lineage acute lymphoblastic leukemia lacking known fusion transcripts, i.e. BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL rearrangements (B-NEG ALL) and the differences between children, adolescents/young adults (AYA) and adults, we analyzed 168 B-NEG ALLs by genome-wide technologies. This approach showed that B-NEG cases carry 10.5 mutations and 9.1 copy-n...

Adenosine deaminase (ADA) is responsible for the deamination of immunosuppressive adenosine to inosine. In human T lymphocytes, ADA is associated with dipeptidyl peptidase IV (CD26). ADA expression and activity were evaluated in regulatory T cells (Treg) and CD4(+) T effector cells (Teff) of patients with head and neck squamous cell cancer (HNSCC). CD4(+)CD39(+) and CD4(+)CD39(neg) T cells were...

با توجه به الزامات زیست‌محیطی، اجتماعی و اقتصادی، طراحی شبکه زنجیره تأمین حلقه‌­بسته پژوهشگران زیادی را خود جذب کرده است. این مسئله بیشتر به‌صورت مجزا از ارزیابی تأمین‌کنندگان موردمطالعه قرار گرفته عوامل مختلفی به‌جز قیمت مانند ویژگی‌های تأمین‌کننده قطعه می‌تواند تأثیر بر عملکرد داشته باشد. در پژوهش یک شامل سایت‌های تولید، جداسازی، بازسازی دفع نظر مدلی تلفیقی سه مرحله ارائه شده نخست روش ترکیبی ...

In the recent years the installation of non-evaporable getter (NEG) coated dipole and quadrupole chambers at the GSI heavy ion synchrotron (SIS 18) have been carried out and ware completed in January 2010. The NEG coated chambers was part of different upgrade activities of the existing UHV system [1]. Those non-evaporable thin film getters, consisting of Ti–Zr–V, are deposited onto the vacuum c...