Hypertrophic scar is characterized by the overgrowth of fibroblasts and often considered as a kind of benign skin tumor, thus chemotherapeutic drugs have been used to treat scars. In view of the similarity, this study aims to investigate whether drug resistance in cancer that contributes to the failure of chemotherapy also exists in hypertrophic scar, and what is the possible mechanism. Fibrobl...

BACKGROUND Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) can provide unique data on the transmural extent of scar/viability. We assessed the prevalence of dysfunctional myocardium, including partial thickness scar, which could contribute to left ventricular contractile dysfunction in patients with heart failure and ischaemic heart disease who denied angina sympt...

OBJECTIVES To describe changes in Cesarean section (CS) scars longitudinally throughout pregnancy, and to relate initial scar measurements, demographic variables and obstetric variables to subsequent changes in scar features and to final pregnancy outcome. METHODS In this prospective observational study we used transvaginal sonography (TVS) to examine the CS scar of 320 consecutive pregnant w...

OBJECTIVE To determine if performing parathyroidectomy surgery through minimal access (MA) incisions has any notable aesthetic or quality-of-life impact on patients compared with conventional access (CON) techniques. DESIGN Paired cohort with (1) a prospective MA incision and scar cohort and (2) a sex- and age-matched (within 3 years) retrospective CON incision and scar cohort. SETTING Tert...

Background: With an aim to reduce the rates of repeat cesarean section in women with a previous scar, prediction of scar rupture or dehiscence is important. If we could predict the risk of rupture by measuring the scar thickness closer to term, we could pursue a trial of scar safely. Aims: To evaluate the use of ultrasound measured thickness of lower uterine segment as one of the predictors of ...

By applying SVF, overcorrection was not needed in fat graft. Stem cell increases effect of tissue regeneration, which contributes to better outcomes of scar revision, flap surgery or skin graft. Furthermore, SVF harvesting requires liposuction and additional cosmetic effect can be expected. Favorable changes in scar scale indicate scar itself can also be improved when combined with conventional...

BACKGROUND The traditional long medial arm incision with its resultant scar is not acceptable. The author presents his long-term experience in performing the posterior scar brachioplasty with fascial suspension. The technique is a modification described by other authors. The aim of the author is to demonstrate the reasons for the choice of the posterior scar technique with fascial suspension. ...

In catheter ablation of scar-related monomorphic ventricular tachycardia (VT), substrate voltage mapping is used to electrically define the scar during sinus rhythm. However, the electrically defined scar may not accurately reflect the anatomical scar. Magnetic resonance-based visualization of the scar may elucidate the 3D anatomical correlation between the fine structural details of the scar a...

The Arp2y3 complex, a stable assembly of two actin-related proteins (Arp2 and Arp3) with five other subunits, caps the pointed end of actin filaments and nucleates actin polymerization with low efficiency. WASp and Scar are two similar proteins that bind the p21 subunit of the Arp2y3 complex, but their effect on the nucleation activity of the complex was not known. We report that full-length, r...

the neck is normally a concave and highly mobile structure. facial and cervical skin is prone to burn scar contracture because of its thin nature. the goal of treatment is to reconstruct this region to achieve a good aesthetic outcome and also normal neck and chin mobilization. this study was conducted to compare the effect of one row of suture and three rows of suture in critical points of the...