Abstract Background Insulin-like growth factor (IGF) has unique and well-known functions in female fertility, according to documents reporting improved yield of oocytes, reinforced quality the embryo, enhanced live births with simultaneous reduction miscarriage. However, there is no detailed information on bio-mechanisms linking such clinical differences. Main body IGF its receptors are express...

The actions of insulin-like growth factor 1 (IGF-1) on protein turnover and of the IGF-1 receptor (IGF-1R) were examined in skeletal muscle of rats with chronic renal failure (CRF) and sham operated (SO), pair-fed controls. Acidemia was prevented in CRF rats with NaHCO3. Serum IGF-1 and skeletal muscle IGF-1 and IGF-1 mRNA were reduced in CRF rats. Dose-response studies revealed impaired stimul...

molecular genetics selection on individual genes is a promising method to genetically improve economically important traits in livestock. the insulin like growth factor-i (igf-i) gene may play important roles in growth of multiple tissues, including muscle cells, cartilage and bone. the objectives of the present study were the estimate the haplotype frequencies of the igf-i gene polymorphisms i...

The IGF-1R [type 1 IGF (insulin-like growth factor) receptor] is activated upon binding to IGF-I and IGF-II leading to cell growth, survival and migration of both normal and cancerous cells. We have characterized the binding interaction between the IGF-1R and its ligands using two high-affinity mouse anti-IGF-1R mAbs (monoclonal antibodies), 7C2 and 9E11. These mAbs both block IGF-I binding to ...

Resumen Objetivos El factor de crecimiento insulínico tipo 1 (IGF-I) es el biomarcador más ampliamente utilizado para diagnóstico y seguimiento los trastornos relacionados con crecimiento, aunque su cuantificación en suero implica una serie dificultades. De este modo, se han observado discrepancias las concentraciones IGF-I según ensayo empleado, especialmente contexto superiores o inferiores a...