Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail. In our experiments, prostaglandin (PG)F(2α) and prostanoid FP receptor agonists (fluprostenol, latanoprost and cloprostenol) produced a decrease in the beating rate. Two prostanoid ...

AbstractThe effect of noise on evolutionary dynamics of Evolutionary Programming(EP) is empirically observed using three different statistical values. These are (1) the averaged best function values, (2) the average of strategy parameters and (3) Hotelling’s T 2 of real values. The classical-EP(CEP), Fast-EP(FEP) and Robust-EP(REP) which stand for Fogel’s EP, Yao and Liu’s EP and our extended E...

Prostaglandin E(2) is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP(1), EP(2), EP(3), and EP(4). Through these receptors, PGE(2) modulates renal hemodynamics and salt and water excretion. The intrarenal distribution and function of EP receptors have been partially characterized, and each receptor has a dist...

Epidermal growth factor (EGF) family members, including epiregulin (EP), play a fundamental role in epithelial tissues; however, their roles in immune responses and the physiological role of EP remain to be elucidated. The skin has a versatile system of immune surveillance. Biologically active IL-1alpha is released to extracellular space upon damage from keratinocytes and is a major player in s...

BACKGROUND AND OBJECTIVE Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. Despite recent improvements in RT efficiency, the side effects of ionizing radiation (IR) in normal tissues are a dose-limiting factor that restricts higher doses in tumor treatment. One approach to enhance the efficiency of RT is the application of radiosensitizers to selectively ...

PURPOSE Previously we showed that epithelial cell adhesion molecule (Ep-CAM), a cell surface molecule, was highly expressed in primary retinoblastoma tumors. In the present study, we studied the genes regulated by Ep-CAM in a retinoblastoma Y79 cell line in vitro using a combination of short interference RNA and microarray technology. METHODS Flow cytometry, quantitative reverse transcriptase...

Murine erythroid precursor cells, stimulated to proliferate in vitro in the absence of added erythropoietin (EP) by the anemia strain of Friend virus (FVA), will subsequently respond to EP by complete erythrocyte differentiation. If not exposed to EP, the erythroid cells divide for about 120 hr in culture, and they maintain the potential for full differentiation in response to EP added at any t...

fabrication and electrochemical characterization of a sensor for the determination of epinephrine (ep), uric acid (ua) and folic acid (fa) is described. the sensor  was prepared using carbon paste electrode (cpe) modified with 3,4-dihydroxybenzaldehyde-2,4-dinitrophenylhydrazone (ddp) and carbon nanotubes (cnts), which makes the modified electrode highly sensitive for the electrochemical detect...

objective: cyclophosphamide (cp) is a chemotherapy drug which causes deleterious effects on testicular tissue and increases free radicals in the body. the aim of this study is to investigate the protective effects of ethyl pyruvate (ep) on testicular improvement in cp treated animals. materials and methods: in this experimental study, 15 male mice (6-8 weeks) were divided into 3 groups. the con...

To compare the signal transduction pathways used by erythropoietin (Ep) and interleukin-3 (IL-3), the cDNA for the murine erythropoietin receptor (EpR) was introduced into the IL-3-responsive cell lines Ba/F3 and DA-3 using retrovirally mediated gene transfer. After selection in G418 and IL-3, clones expressing comparable levels of cell surface EpR were identified using biotinylated Ep and flow...