Many statistical methods have been developed to map multiple quantitative trait loci (QTL) in experimental cross populations. Among these methods, multiple-interval mapping (MIM) can map QTL with epistasis simultaneously. However, the previous implementation of MIM is for continuously distributed traits. In this study we extend MIM to ordinal traits on the basis of a threshold model. The method...

High temperature strength is one of the critical technical issues to apply metal injection molding (MIM) Nickel-based superalloy IN713. In this study, through investigating microstructure and high IN713-MIM materials in detail, we developed technique promote grain growth. experiments using IN713C-MIM materials, tensile creep were remarkably inferior castings. The deformation mechanism revealed ...

Negative lifestyle habits (potential risks for chronic kidney disease, CKD) are rarely modified by physicians in a conventional health-care model (CHCM). Multidisciplinary strategies may have better results; however, there is no information on their application in the early stages of CKD. Thus, the aim of this study was to compare a multiple intervention model versus CHCM on lifestyle and renal...

The interaction of human adenovirus (HAdV)-C5 and many other adenoviruses with blood coagulation factors (e.g., human factor X, FX) involves the binding of their GLA domain to the hexon capsomers, resulting in high levels of hepatotropism and potential hepatotoxicity. In this study, we tested the possibility of preventing these undesirable effects by using a GLA-mimicking peptide as a competito...

We demonstrate lasing in Metal-Insulator-Metal (MIM) waveguides filled with electrically pumped semiconductor cores, with core width dimensions below the diffraction limit. Furthermore these waveguides propagate a transverse magnetic (TM0) or so called gap plasmon mode [1-4]. Hence we show that losses in sub-wavelength MIM waveguides can be overcome to create small plasmon mode lasers at wavele...

In this paper, we review the construction of low-dimensional manifolds of reduced description for equations of chemical kinetics from the standpoint of the method of invariant manifold (MIM). MIM is based on a formulation of the condition of invariance as an equation, and its solution by Newton iterations. A review of existing alternative methods is extended by a thermodynamically consistent ve...

To the Editor : Charcot–Marie–Tooth type 1 (CMT1), the most frequent hereditary peripheral neuropathy, is characterized by marked clinical and genetic heterogeneity (1). Mutations in genes coding for peripheral myelin protein 22 (PMP22 ; MIM 601097), myelin protein zero (MPZ/P0 ; MIM 159440) and connexin 32 or gap junction beta 1 (Cx32/GJB1 ; MIM 304040) cause CMT1A, CMT1B and CMTX, the most co...

We demonstrate the realization of on-chip plasmonic analogue of electromagnetically induced transparency (EIT) in integrated plasmonic devices using detuned Fabry-Perot resonators aperture-side-coupled to a metal-insulator-metal (MIM) waveguide, with the transmission peak occurring at the intermediate wavelength. Strong MIM mode confinement along with localized side-coupling allows one to reali...

This research-in-progress paper studies the active and passive usage of mobile instant messaging (MIM) applications. Grounded on two-factor theory and three-factor theory, we propose the features of MIM applications influence the active/passive usage of MIM applications through users’ satisfaction and dissatisfaction. The proposed features are categorized into three factors: exciting factors wh...

A speciic class of multimedia applications is expected to be of importance for future communication networks: Multi-Party Interactive Multimedia (MIM). Based on the isolation and characterization of MIM applications, concrete network support requirements are derived in this paper. The varying degree of connectivity, the vastly diierent sizes in terms of participants and the reliance on a guaran...