It is well recognized that nitric oxide (NO) is involved in tumor progression, including melanoma. Measurement of proliferative and metastatic capacity by MTS and Matrigel invasion assays, respectively, was done and showed that NO-treated melanoma cells exhibited a higher capacity compared with control, especially metastatic Lu1205 cells. Apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE...

Abasic (AP) sites in DNA arise from spontaneous reactions or the action of DNA glycosylases and represent a loss of genetic information. The AP sites can be mutagenic or cytotoxic, and their repair is initiated by class II AP endonucleases, which incise immediately 5' to AP sites. The main enzyme of S. cerevisiae. Apn1, provides cellular resistance to oxidants (e.g., H2O2) or alkylating agents,...

Abstract One of the proposed mechanisms to explain multidecadal variability observed in sea surface temperature North Atlantic Ocean consists a large-scale low-frequency internal mode spontaneously developing because baroclinic instability time-mean circulation. Even though this has been extensively studied terms buoyancy variance budget, its energetic properties remain poorly known. Here we pe...

ABSTRACT Abdominoperineal excision (APE) is used to resect cancers in the distal rectum and anus where sphincterpreserving surgery is not possible. It is associated with increased local recurrence rates compared to anterior resection. The extralevator abdominoperineal excision (ELAPE) was developed to reduce local recurrence and was widely adopted without sound evidence. AIM To compare the sh...

PURPOSE Syncope is an atypical presentation for acute pulmonary embolism (APE). There are conflicting data concerning syncope and prognosis of APE. PATIENTS AND METHODS One hundred and seventy-nine consecutive patients aged 22-96 years (median, 68 years) with APE were retrospectively enrolled in the study. RESULTS Prevalence of syncope was 13% (n=23) at the time of presentation. Compared to...

At present there is consent that patients with acute pulmonary embolism (APE) and hemodynamic instability have poor prognosis and benefit from thrombolytic therapy or embolectomy, whereas hemodynamically stable patients without echocardiographic signs of right ventricular overload/dysfunction (RVO) have good prognosis and should be treated with anticoagulation alone. The optimal treatment for s...

Perhaps the last major effort to save the world’s great apes from extinction has been launched at a recent meeting held in the Democratic Republic of the Congo, one of 23 home states of the great apes. The meeting included an unusually broad range of interests for a conservation issue, with businesses, industry and communities joining up with scientists, environmental agencies and UN bodies to ...

Helicobacter pylori infection causes inflammation and increases the expression of IL-8 in human gastric epithelial cells. H. pylori activates NF-kappaB and AP-1, essential transcriptional factors in H. pylori-induced IL-8 gene transcription. Although colonization creates a local oxidative stress, the molecular basis for the transition from infection to the expression of redox-sensitive cytokine...

Exactly solving the absolute minimum potential energy state (Lorenz reference state) is a difficult problem because of the nonlinear nature of the equation of state of seawater. This problem has been solved recently but the algorithm comes at a high computational cost. As the first part of this study, the authors develop an algorithm that is;10–10 times faster,making it useful for energy diagno...

Description Functions for reading, writing, plotting, and manipulating phylogenetic trees, analyses of comparative data in a phylogenetic framework, ancestral character analyses, analyses of diversification and macroevolution, computing distances from DNA sequences, reading and writing nucleotide sequences as well as importing from BioConductor, and several tools such as Mantel's test, generali...