BACKGROUND Information on health-related quality of life is becoming increasingly important in children with cerebral palsy. This study investigated the relationship between activity limitation and health-related quality of life in school-aged children with cerebral palsy. METHODS Data were collected from 71 children aged 6-15 years with cerebral palsy. Activity limitations were assessed usin...

Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells express nine transmembrane AC (mAC) isoforms (AC1-9) and a soluble AC (sAC, also referred to as AC10). This review will largely focus on mACs. mACs are activated by the G-protein Gαs and regulated by multiple mechanisms. mACs are differentially expressed in tissues and regulate numerous and diverse cell functio...

The standard treatment for most advanced cancers is multidrug therapy. Unfortunately, combinations in the clinic often do not perform as predicted. Therefore, to complement identifying rational drug combinations based on biological assumptions, we hypothesized that a functional screen of drug combinations, without limits on combination sizes, will aid the identification of effective drug cockta...

UNLABELLED The Bimanual Fine Motor Function (BFMF) is currently the principal classification of hand function recorded by the Surveillance of Cerebral Palsy in Europe (SCPE) register. The BFMF is used in a number of epidemiological studies, but has not yet been validated. AIMS To examine aspects of construct and content validity of the BFMF. METHODS AND RESULTS Construct validity of the BFM...

This paper develops several new techniques of cryptanalyzing MACs based on block ciphers, and is divided into two parts. The first part presents new distinguishers of the MAC construction Alred and its specific instance Alpha-MAC based on AES. For the Alred construction, we first describe a general distinguishing attack which leads to a forgery attack directly with the complexity of the birthda...

We present an extension of magic angle coil spinning (MACS) solid-state NMR spectroscopy to double-resonance experiments, enabling implementation of powerful double-resonance solid-state NMR methodologies including cross polarization, proton decoupling, and two-dimensional correlation spectroscopy etc., while still enjoying the merits that are intrinsic to MACS, such as high concentration sensi...

Submit Manuscript | http://medcraveonline.com Abbreviations: WHO: World Health Organization; ROS: Reactive Oxygen Species; PS: Phosphatidylserine; EPS: Externalization of Phosphatidylserine; ART: Assisted Reproduction Techniques; IUI: Intra-Uterine Insemination; IVF: In Vitro Fertilization; ICSI: Intracytoplasmic Sperm Injection; PICSI: Physiologic Intracytoplasmic Sperm Injection; SU: Swim-Up;...

Multi-atom catalysts (MACs) with active sites consisting of two to tens metal atoms have molecule-like electronic structure and promising catalytic properties. In article number 2000213, Xiao Yan, Feng Hou, Ji Liang co-workers present the recent progress MACs in energy-related electrocatalysis, including synthesis, characterization applications. Challenges prospects for are also presented shed ...

Strategies using carbon-based nanomaterials as carriers for delivering chemotherapeutic drugs to cancers have been described well. Here a novel magnetic lymphatic-targeting drug-delivery system, based on functionalised carbon nanotubes (fCNTs), is presented with the aim of improving the outcome of cancer with lymph node involvement. The potential therapeutic effect of gemcitabine (GEM) loading ...

We have investigated the potential of PAC-based vectors as a route to the incorporation of a gene in a mammalian artificial chromosome (MAC). Previously we demonstrated that a PAC (PAC7c5) containing alpha-satellite DNA generated mitotically stable MACs in human cells. To determine whether a functional HPRT gene could be assembled in a MAC, PAC7c5 was co-transfected with a second PAC containing...