Several studies have demonstrated that nitric oxide (NO) is involved in hyperalgesia induced by NMDA activity in Morphine tolerance and NO synthase inhibitors can attenuate hyperalgesia in morphine tolerance. In addition, one of the possible mechanisms in morphine tolerance is reduction of GABA inhibitory effect. For this reason, we used GABA agonists (muscimol and baclofen) to investigate the ...

Several studies have demonstrated that nitric oxide (NO) is involved in hyperalgesia induced by NMDA activity in Morphine tolerance and NO synthase inhibitors can attenuate hyperalgesia in morphine tolerance. In addition, one of the possible mechanisms in morphine tolerance is reduction of GABA inhibitory effect. For this reason, we used GABA agonists (muscimol and baclofen) to investigate the ...

although many studies have highlighted the role of gamma-aminobutyric acid (gaba) in the pathophysiology of psychosis, there is no drug-induced animal model in which gaba is manipulated. in this article we propose a hypothetical animal model for psychosis based on the silencing gabaergic system.  the presentation also suggest pre-pulse inhibition test as a preferred approach towards proving thi...

γ-aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. in this study baclofen was easily synthesize...

introduction: in female rats sensitivity to antinociceptive treatment varies during estrous cycle stages. the role of gaba through gabab receptor in nociception has been established. the aim of the present study is to investigate the effect of intercerebroventicular injection of gabab receptor agonist (baclofen) and gabab antagonist (cgp35348) on pain sensitivity during different stages of estr...

GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes, GABA(B1) and GABA(B2), has revealed a novel requirement for GABA(B) receptor signalling. Studies have demonstrated that the two receptor subunits associate as a GABA(B1)/GABA(B2) heterodimer to form a functional GABA(B) receptor. In this ...

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system that has significant beneficial effect on human health. Traditional microbial GABA synthesis requires continuous oxygen supplementation. Here, new anaerobic platform for production was established with engineered C. tyrobutyricum ATCC 25755, which considered an ideal microbial-cell fact...

Abstract Background Gamma-aminobutyric acid (GABA) is an important bio-product used in pharmaceuticals and functional foods as a precursor of the biodegradable plastic polyamide 4. Glutamate decarboxylase (GAD) converts l -glutamate ( -Glu) into GABA via decarboxylation. Compared with other methods, develop bioconversion platform to produce considerable interest for industrial use. Results Thre...

In the hippocampus, interneurons provide synaptic inhibition via the transmitter GABA, which can activate GABA(A) and GABA(B) receptors (GABA(A)Rs and GABA(B)Rs). Generally, however, GABA released by a single interneuron activates only GABA(A)Rs on its targets, despite the abundance of GABA(B)RS. Here, I show that during hippocampal rhythmic activity, simultaneous release of GABA from several i...

Watercore is a physiological disorder which often occurs in Rosaceae fruits, and it causes hypoxia stress, promoting fruit decay. γ-aminobutyric acid (GABA) was reported as being involved different abiotic stresses, glutamate decarboxylase (GAD) the key enzyme of GABA synthesis plants. Our previous transcriptome analysis found that PpGAD2 significantly induced watercore fruit; however, mechanis...