ABSTRACT We present a study of photochemical hazes exoplanet atmospheres based on self-consistent model including haze microphysics, disequilibrium chemistry, and radiative feedbacks. derive the properties required to match Hubble Space Telescope observations 10 hot-Jupiters. HAT-P-12b, HD-189733b, HD-209458b, WASP-6b require mass fluxes between 5 × 10?15 9 10?12 g cm?2 s?1 observations. WASP-1...

Endothelial cells (ECs) form a monolayer that serves as a barrier between the blood and the underlying tissue. ECs tightly regulate their cell-cell junctions, controlling the passage of soluble materials and immune cells across the monolayer barrier. We studied the role of N-WASP, a key regulator of Arp2/3 complex and actin assembly, in EC monolayers. We report that N-WASP regulates endothelial...

The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on the presence of the G protein-binding domain. Cellular expression of epitope-ta...

The Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by thrombocytopenia, eczema, disorders in cell-mediated and humoral immunity, and a proclivity to lymphoproliferative disease. The gene responsible encodes a 53-kD proline-rich protein of unknown function (WASP). We produced a FLAG-WASP fusion protein that was used to immunize mice and produce mAbs against WASP. Using mono...

Neural Wiskott-Aldrich syndrome protein (N-WASP) is involved in tight regulation of actin polymerization and dynamics. N-WASP activity is regulated by intramolecular interaction, binding to small GTPases and tyrosine phosphorylation. Here, we report on a novel regulatory mechanism; we demonstrate that N-WASP interacts with dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A). ...

Clathrin-mediated endocytosis (CME) involves spatially and temporally restricted molecular dynamics, to which protein kinases and actin contribute. However, whether and how these two elements merge to properly execute CME remains unknown. Here, we show that neural Wiskott-Aldrich syndrome protein (N-WASP) and casein kinase 2 (CK2) form a complex and localize to clathrin-coated vesicles. N-WASP ...

El síndrome de Wiskott-Aldrich (WAS) es una inmunodeficiencia primaria humana ligada al cromosoma X, caracterizada por inmunodeficiencia, microtrombocitopenia y eccema. El gen causante de WAS (WASP) codifica una proteína de 502 residuos llamada WASp. WASp da nombre a una familia de proteínas recientemente definida e involucrada en la transducción de señales desde la membrana celular al citoesqu...

the family of pteromalidae (hym: chalcidoidea) is one of the largest families of parasitic wasp. members of this family wasp comprise of important natural enemies of many harmful insects in major insect orders such as coleoptera, diptera, lepidoptera, hymenoptera and homoptera; therefore they have an important role in biological control of agricultural pests. the chalcid wasps belonging to this...

Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT), caused by mutations of the WAS protein (WASP) gene, represent different phenotypes of the same disease. To demonstrate a phenotype/genotype correlation, we determined WASP gene mutations in 48 unrelated WAS families. Mutations included missense (20 families) and nonsense (eight) mutations located mostly in exons 1 to 4, and spl...

Wiskott-Aldrich syndrome protein (WASp) is an actin nucleation promoting factor that is required for macrophages to directionally migrate towards various chemoattractants. The chemotaxis defect of WASp-deficient cells and its activation by Cdc42 in vivo suggest that WASp plays a role in directional sensing, however, its precise role in macrophage chemotaxis is still unclear. Using shRNA-mediate...