OBJECTIVES This study sought to investigate the characteristics of in-stent restenosis (ISR) after drug-eluting stent (DES) implantation for femoropopliteal (FP) lesions, and to examine 1-year prognosis after repeat endovascular therapy (re-EVT) for these DES-ISR. BACKGROUND The morphology of DES-ISR and its association with clinical outcomes after re-EVT have not been well examined. METHOD...

The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the ability to synthesize C1q, which acts as a link between endovascular trophoblast and DECs favouring th...

We are interested in the risk of large losses of certain common financial portfolios (e.g. credit portfolios with default risk). In these cases, we would like to estimate a risk statistic called Value-at-Risk (VaRα) at an extremely high risk level α (typically 99.99%). This high risk level corresponds to rare events for which it is difficult or impossible to obtain data. We first use Monte Carl...

The dual power flow wind energy conversion system (DPF-WECS) is a novel system which is based on the electrical variable transmission (EVT) machine. The proposed sensorless control for the DPF-WECS is based on the model reference adaptive system (MRAS) observer by combining the sliding mode (SM) theory. The SM-MRAS observer is on account of the calculations without the requirement of the propor...

In a meta-analysis of individual patient data from 5 randomized controlled trials, endovascular treatment (EVT) mainly using a stent retriever achieved successful recanalization in 71.1% of patients suffering from acute stroke due to anterior circulation large artery occlusion (LAO). However, EVT still failed in 28.9% of LAO cases in those 5 successful trials. Stent retriever failure may occur ...

Tremulous voice is characteristically associated with essential tremor, and is referred to as essential vocal tremor (EVT). Current estimates suggest that up to 40% of individuals diagnosed with essential tremor also present with EVT, which is associated with an impaired quality of life. Traditional EVT treatments have demonstrated limited success in long-term management of symptoms. However, v...

See related article, p XXX Whether intravenous or endovascular stroke therapy should be withhold in patients with acute ischemic stroke with blood pressure (BP) levels above certain thresholds is one of the major unresolved issues in acute stroke management. The post hoc analysis of data of the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic St...

Introduction Endovascular therapy (EVT) is now evidence based in anterior circulation stroke caused by large vessel occlusion. Outcome is related to infarct size, but data on predictors of infarct growth is limited. We analyzed our cohort of EVT treated patients primarily selected by magnetic resonance imaging (MRI) to examine predictors of infarct growth and the association between infarct siz...

Human cytomegalovirus (HCMV) downregulates the class I major histocompatibility complexes (MHCs), HLA-A and -B, in infected fibroblasts to escape from antigen-specific cytotoxic T lymphocytes. The HCMV genes responsible for the downregulation of MHCs are US2, US3, US6, and US11, which encode type I membrane proteins working at the endoplasmic reticulum (ER). However, it is largely unknown wheth...

BACKGROUND Sarpogrelate is expected to reduce restenosis by protecting blood vessels from oxidative stress and vascular endothelial dysfunction as well as by acting as an antiplatelet agent after endovascular treatment (EVT). This trial was designed to compare aspirin plus sustained-release (SR) sarpogrelate with aspirin plus clopidogrel for the prevention of restenosis in patients with femoro-...