The E2A gene products, E12 and E47, are critical regulators of B cell development. However, it remains elusive whether E12 and E47 have overlapping and/or distinct functions during B lymphopoiesis. We have generated mice deficient for either E12 or E47 and examined their roles in B cell maturation. We show that E47 is essential for developmental progression at the prepro-B cell stage, whereas E...

Nuclear import of karyophilic proteins is carried out by a variety of mechanisms. We previously showed that two basic helix-loop-helix proteins, NeuroD1 and E47, synergistically affect each other's nuclear import. In this study, we dissected the molecular pathways underlying nuclear import of the NeuroD1/E47 heterodimer. In vitro nuclear import assays indicated that importin α family members ar...

Allelic exclusion of antigen-receptor genes is ensured primarily by monoallelic locus activation upon rearrangement and subsequently by feedback inhibition of continued rearrangement. Here, we demonstrated that the basic helix-loop-helix protein, E47, promoted T cell receptor beta (TCRbeta) gene rearrangement by directly binding to target gene segments to increase chromatin accessibility in a d...

سابقه و هدف: امروزه صنعتی شدن توسعه شهرنشینی باعث آلودگی هوا در اکثر کلان‌شهرهای جهان شده است سالانه میلیون­ ها نفر به ­علت جان خود را از دست می­ دهند. ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﻣﺤﺪود ﺑﻮدن ﺷﺒﻜﻪ اﻳﺴﺘﮕﺎه‌ﻫﺎى ﭘﺎﻳﺶ آﻻﻳﻨﺪه‌ﻫﺎى ﻫﻮا ﻏﻴﺮ اﻗﺘﺼﺎدى اﻓﺰاﻳﺶ ﺗﻌﺪاد این اﻳﺴــﺘﮕﺎه‌ﻫا سطح شهرها، دﺳﺖ‌ﻳﺎﺑﻰ ﭘﻮﺷــﺶ ﻣﻜﺎﻧﻰ زﻣﺎﻧﻰ ﻣﻨﺎﺳــﺐ برای ﻧﺸﺎن دادن ﺗﻐﻴﻴﺮات ﻏﻠﻈﺖ ذرات آلاینده ﺑﺴﻴﺎر دﺷﻮار اﺳﺖ. بر اساس پژوهش حاضر با هدف تهیه نقشه ­ها...

The transcription factor Foxp3 dominantly controls regulatory T (Treg) cell function, and only its continuous expression guarantees the maintenance of full Treg cell-suppressive capacity. However, transcriptional regulators maintaining Foxp3 transcription are incompletely described. Here, we report that high E47 transcription factor activity in Treg cells resulted in unstable Foxp3 expression. ...