Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as the transcriptional template for all viral RNAs. CCC DNA is converted from a relaxed circular (RC) DNA in the virion early during infection as well as from RC DNA in intracellular progeny nucleocapsids via an intracellular amplification pathway. Curre...

BACKGROUND Cholangiocarcinoma (CCC) is the second most common type of primary liver cancer, and is associated with a high rate of mortality due to the difficulty of early detection and resistance to chemotherapeutic agents. To evaluate the possibility for new therapeutic strategies, we examined the combined effect of gefitinib and gemcitabine on CCC. MATERIALS AND METHODS The effect of gefiti...

The calculation of the main circuit parameters is basic part engineering design for high voltage direct current (HVDC) transmission systems. Compared to conventional line commutated converter (LCC), application capacitor (CCC) can reduce probability commutation failures and shunt reactive compensation. This paper proposes a method CCC-based HVDC system. Firstly, topology CCC-HVDC system describ...

Networks have become ubiquitous in many real world applications and to cluster similar networks is an important problem. There are various properties of graphs such as clustering coefficient (CC), density, arboricity, etc. We introduce a measure, Clique Conversion Coefficient (CCC), which captures the clique forming tendency of nodes in an undirected graph. CCC could either be used as a weighte...

The elimination of viral covalently closed circular DNA (CCC DNA) from the nucleus of infected hepatocytes is an obstacle to achieving sustained viral clearance during antiviral therapy of chronic hepatitis B virus (HBV) infection. The aim of our study was to determine whether treatment with adefovir, a new acyclic nucleoside phosphonate, the prodrug of which, adefovir dipivoxil, is in clinical...

Resistance of ovarian clear cell carcinoma (CCC) to platinum-based chemotherapy is associated with poor prognosis, and an effective treatment for advanced disease is urgently needed. HER2/neu is up-regulated more often in CCC than in other histologic types of epithelial ovarian cancer. The purpose of this study was to assess possible treatment for ovarian CCC with the anti-HER2 antibody trastuz...

OBJECTIVE Drug use and receipt of highly active antiretroviral therapy (HAART) were assessed in HIV-infected persons from the Comprehensive Care Center (CCC; Nashville, TN) and Johns Hopkins University HIV Clinic (JHU; Baltimore, MD) between 1999 and 2005. METHODS Participants with and without injection drug use (IDU) history in the CCC and JHU cohorts were evaluated. Additional analysis of p...

Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism. CCC DNA formation could require enzymatic activities of the viral reverse transcriptase (RT), or cellular DNA repair enzymes, or both. Physical mapping of the 5' and 3' ends of RC DNA and sequence analysis of CCC DNA revealed that CCC DNA...

Chlormequat (cycocel or CCC), the plant growth retardant, was evaluated for its ability to control plant height in Brassica oleracea cultivar ‘Kamome White’ and ‘Nagoya Red’. Different concentrations of CCC (0, 500, 1000 and 1500 mg/L) were sprayed and drenched on plants 40 days after transplanting. Data were recorded the 60 and 90 days after transplanting. The 1500 mg/L of CCC resulted in abou...

Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for diagnosis and prognosis in patients with several types of cancers. Further, many...