OBJECTIVES Bowel cleansing is necessary before colonoscopy, but is a burden to patients because of the long cleansing time and large dose volume. A low-volume (2 L) hypertonic polyethylene glycol-ascorbic acid solution (PEG-Asc) has been introduced, but its possible dehydration effects have not been quantitatively studied. We compared the efficacy and safety including the dehydration risk betwe...

Bauhinia purprea agglutinin (BPA) is a well-known lectin that recognizes galactosyl glycoproteins and glycolipids. In the present study, we firstly found that BPA bound to human prostate cancer specimens but not to normal prostate ones. Therefore, we sought to develop BPA-PEG-modified liposomes (BPA-PEG-LP) encapsulating anticancer drugs for the treatment of prostate cancer. We examined the tum...

The adsorption of proteins, in particular fibronectin (Fn), was studied on poly(ethylene glycol) (PEG, 5kDa)-grafted surfaces, and was correlated with the adhesion behaviors of smooth muscle cells (SMCs). The PEG molecules were covalently grafted on aldehyde-activated substrates with different densities of amino groups. The thickness of PEG layer increased nearly 10 fold in a hydrated state, re...

Percutaneous endoscopic gastrostomy (PEG) is widely used in patients requiring long-term tube feeding. Traditional PEG studies usually focused on practical, technical, and ethical issues. There have been little epidemiological studies on PEG utilization and services in Asia. We evaluated the changes in PEG utilization, patient selection, patient characteristics, and medical service in Taiwan fr...

Covalent attachment of poly(ethylene glycol) (PEG) molecules to drugs, proteins, and liposomes is a proven technology for improving their bioavailability, safety, and efficacy. Qualitative and quantitative analysis of PEG-derivatized molecules is important for both drug development and clinical applications. We previously reported the development of a monoclonal IgM antibody (AGP3) to PEG. We n...

Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeutic efficacy. Although antibodies with specificity for PEG may compromise the safety and effectiveness of PEGylated medicines, the prevalence of pre-existing anti-PEG antibodies in healthy individuals is unclear. Chimeric human anti-PEG antibody standards w...

Excellent strength regenerated alginate composite fibers mixed with Poly (ethylene glycol) grafted cellulose nanocrystals (CNC-g-PEG) were prepared through a simple and scalable blending strategy. Firstly, high modulus (CNCs) fabricated based on waste cotton fabrics by the chemical treatment. (PEG) different molecular weight was onto CNC surface. The from CNC-g-PEG/sodium spinning dope wet spin...

Biodegradable macromolecular Gd(III) complexes, Gd-DTPA cystine copolymers (GDCP), were grafted with PEG of different sizes to modify the physicochemical properties and in vivo MRI contrast enhancement of the agents and to study the effect of PEG chain length on these properties. Three new PEG-grafted biodegradable macromolecular gadolinium(III) complexes were synthesized and characterized as b...

A modi®ed two stage in vitro digestion method was used to study the effects of rate of PEG addition (0±1100 mg/g DM) on dry matter (IVDMD) and nitrogen digestibility (IVND) of freeze dried leaf materialfromactivelygrowingshootsofCalliandracalothyrsus (Calliandra)andLeucaenaleucocephala cv. Cunningham (Leucaena). For both species, IVDMD and IVND increased asymptotically with PEG rate; the IVND r...

An 84-year-old woman with vascular dementia and percutaneous endoscopic gastrostomy (PEG) placement 2 months prior presented with a fecal odor from the PEG tube and diarrhea at each feeding. No feces output from the PEG tube or peristomal leakage was noted. Computed tomography of the abdomen showed penetration of the PEG tube through the transverse colon to the stomach, without surrounding infl...