Spatiotemporally regulated actomyosin contractility generates the forces that drive epithelial cell rearrangements and tissue remodeling. Phosphorylation of the myosin II regulatory light chain (RLC) promotes the assembly of myosin monomers into active contractile filaments and is an essential mechanism regulating the level of myosin activity. However, the effects of phosphorylation on myosin l...

A closed form expression for the propagation delay of a CMOS gate driving a distributed RLC line is introduced that is within 7% of SPICE simulations for a wide range of RLC loads. This expression is based on the alpha power law for deep submicrometer technologies. It is shown that the error in the propagation delay if inductance is neglected and the interconnect is treated as a distributed RC ...

Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease characterized by left ventricular wall thickening, myofilament disarray and abnormal echocardiography findings. Molecular genetic studies have defined FHC as a disease of the sarcomere caused by mutations in all major sarcomeric proteins, such as ┚-myosin heavy chain (44%), myosin binding protein C (35%), regulatory lig...

Abstract— A Fourier analysis of on-chip signals in CMOS integrated circuits is presented in this paper. It is demonstrated that on-chip signals can be approximated by a Fourier series up to the th harmonic component. The effective load impedance characterizing a distributed RC and RLC line driven by a CMOS logic gate is based on a Fourier analysis of the on-chip signals. The voltage waveform ba...

This paper proposes a RLC/MAC (Radio Link Control/Multiple Access Control) protocol architecture suitable for a wireless IP network. The RLC and MAC protocols have been designed to support packet transmission on an air interface. The MAC protocol uses a reservation technique to increase the multiplexing efficiency by minimising collisions. The RLC protocol is based on selective repeat technique...

Phosphorylation of the regulatory light chain (RLC) activates the actin-dependent ATPase activity of Dictyostelium myosin II. To elucidate this regulatory mechanism, we characterized two mutant myosins, MyDeltaC1225 and MyDeltaC1528, which are truncated at Ala-1224 and Ser-1527, respectively. These mutant myosins do not contain the C-terminal assembly domain and thus are unable to form filament...

Today’s high-speed very large scale integration interconnects are becoming inductively dominated (moderate Q) resistance–inductance–capacitance (RLC) transmission lines. The time-domain system responses of RLC interconnect lines driving load capacitances cannot be accurately represented by using a finite number of poles with exception for a particular case of RC-time-constant-dominant (low Q) R...

Evaluations of red light camera (RLC) traffic safety programs have produced mixed results. Some conclude RLCs were associated with significant increases in motor vehicle crashes and injury crashes, whereas other research reports safety benefits. To understand the difference in findings, the present analysis assessed whether standards required for internal validity in quasi-experimental public h...

Morphogenesis is characterized by orchestrated changes in the shape and position of individual cells. Many of these movements are thought to be powered by motor proteins. However, in metazoans, it is often difficult to match specific motors with the movements they drive. The nonmuscle myosin II heavy chain (MHC encoded by zipper is required for cell sheet movements in Drosophila embryos. To det...