In the present work, metronidazole and doxycycline with different antibacterial spectra are proposed to be formulated as combination therapy to have a broader antibacterial therapy, which is effective against both aerobic and anaerobic periodontal microflora. Simultaneous use of metronidazole and doxycycline is effective against wide range of periodontal pathogens. Metronidazole and doxycycline...

The occurrence of strains resistant to metronidazole is causing failure of the 4-drug regimen for eradication of Helicobacter pylori in the Islamic Republic of Iran. This study compared the in vitro efficacy of furazolidone with metronidazole, clarithromycin, amoxicillin and tetracycline in 70 H. pylori isolates from dyspeptic patients. Of the isolates, 33% were resistant to metronidazole but a...

The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant. rdxA, frxA, and fdxB k...

The minimal inhibitory concentrations of Rodogyl (composite tablet of metronidazole and spiramycin), metronidazole-spiramycin mixture, spiramycin, metronidazole, and tetracycline were determined for selected putative periodontopathic microorganisms. Rodogyl was active against almost all strains, including Bacteroides species and the anaerobic spirochetes. Synergism of the component drugs in the...

metronidazole and furazolidone were compared for efficacy in 268 seven to 11 year old children infected with giardiasis. with metronidazole the cure rate was 82.3% and 80.0% in boys and girls respectively, while furazolidone showed an efficacy of74.4% and 71. 7% in the corresponding groups. the overall efficacy was 81.1 % with metronidazole and 73.3% with furazolidone. there were no significant...

Metronidazole in METRONIDAZOLE I.V. Infusion 500mg/100ml was determined by Spectrophotometric method. Being a very simple, reliable and sensitive method was developed and adopted to perform the analysis of METRONIDAZOLE I.V. Infusion 500mg/100ml. The Spectrophotometric method described was found to be simple, sensitive and accurate. Therefore this could be applied for the determination of METRO...

There are no generally accepted regimens for the treatment of H. pylori infection in patients with gastritis or duodenal ulcers. However, metronidazole based regimens have been reported to be among the most successful. Resistance to metronidazole, clarithromycin, and amoxicillin was determined for 46 clinical isolates of Helicobacter pylori in Saudi Arabia and tested by E test. Of these isolate...

Metronidazole is widely used to treat protozoan and fungal infections. As an antibacterial drug, it is used mainly against anaerobes. Among anaerobes, the Bacteroides fragilis group is the most relevant in terms of frequency of recovery and antimicrobial resistance patterns. The use of metronidazole and other antimicrobial drugs induces morphological changes in this bacterial group. The present...

Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes. Encephalopathy associated with metronidazole administration occurs rarely and depends on the cumulative metronidazole dose, and most patients with this condition recover rapidly after discontinuation of therapy. Because metronidazole is metabolized in the liver and can be transported...