نتایج جستجو برای: مادۀ 143 قمم
تعداد نتایج: 13272 فیلتر نتایج به سال:
BACKGROUND Prostate cancer has become a serious threat to the life of patients. microRNAs are small non-coding RNA molecules that regulate the growth and apoptosis of cells. We aimed to investigate the regulation and mechanism of microRNA (miR-143) in the proliferation and apoptosis of prostate cancer LNCap cells. MATERIAL AND METHODS miR-143 and control scramble miRNA were synthesized and resp...

 Purpose: To investigate the regulatory effect and molecular mechanism of miR-143-5p in colorectal cancer (CRC) progression.
 Methods: Expression CRC cell lines SW620 HCT116 was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Stable overexpression mediated lentivirus. The effects on proliferation, migration, invasion, epithelial- mesenchymal transition (EMT)...
We have previously shown that miR-143 is downregulated in colorectal cancer and that miR-143 overexpression in HCT116 cells increases sensitivity to 5-fluorouracil, reduces cell viability and increases apoptosis in vitro. In the present study, we evaluated the role of miR-143 over-expression on HCT116 xenograft tumor growth in nude mice. HCT116 cells with stable miR-143 over-expression (over-14...
RATIONALE The miR-143/145 cluster is highly expressed in smooth muscle cells (SMCs), where it regulates phenotypic switch and vascular homeostasis. Whether it plays a role in neighboring endothelial cells (ECs) is still unknown. OBJECTIVE To determine whether SMCs control EC functions through passage of miR-143 and miR-145. METHODS AND RESULTS We used cocultures of SMCs and ECs under differ...
شوری آب و خاک از مهمترین تنشها برای رشد گیاهان در مناطق خشک و نیمهخشک به شمار می رود. به منظور بررسی تأثیر شوری آب بر برخی صفات فیزیولوژیک و تولید مادۀ خشک ژنوتیپهای بزرک، آزمایشی به صورت فاکتوریل در قالب طرح بلوکهای کامل تصادفی اجرا شد. تیمارهای بررسی شده در این آزمایش، شوری در چهار سطح (0، 35، 70 و 105 میلی مولار نمک طعام خالص) به عنوان عامل اول؛ و ژنوتیپهای c1،c2،c3، b، خراسان و 33 به...
UNLABELLED It is increasingly clear that hepatocellular carcinoma (HCC) has a distinct microRNA (miRNA) expression profile that is involved in malignancy; however, little is known about how functional miRNA modulates the metastasis of hepatitis B virus (HBV)-related HCC (HBV-HCC). In the present study, we demonstrate that the levels of miRNA-143 (miR-143) are dramatically increased in metastati...
MicroRNAs (miRNAs) regulate a wide variety of biological processes, including tumourigenesis. Altered miRNA expression is associated with deregulation of signalling pathways, which in turn cause abnormal cell growth and de-differentiation, contributing to cancer. miR-143 and miR-145 are anti-tumourigenic and influence the sensitivity of tumour cells to chemotherapy and targeted therapy. Compara...
MicroRNAs (miRNAs) are endogenously expressed 20–24 nucleotide RNAs thought to repress protein translation through binding to a target mRNA (1–3). Only a few of the more than 250 predicted human miRNAs have been assigned any biological function. In an effort to uncover miRNAs important during adipocyte differentiation, antisense oligonucleotides (ASOs) targeting 86 human miRNAs were transfected...
Osteosarcoma is one primary malignant bone tumor that commonly occurs in children and teenagers. Its high malignancy, invasiveness and metastasis all lead to unfavorable prognosis even with combined treatment. Cisplatin is a common chemotherapy agent in treating various solid tumors including ovarian, pulmonary, nasopharyngeal, esophageal, thyroid cancers and osteosarcoma, but leaving its mecha...
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