Interleukin-2 (IL-2), a cytokine that induces natural killer cells termed lymphokine-activated killer (LAK) cells, is in use as an anticancer agent. During IL-2 therapy, adverse effects, such as vasodilatation and hypotension, are common. Previous studies suggest that these effects are due to nitric oxide (NO). Therefore a model of IL-2-induced hyperdynamic response in sheep was developed to te...

CONTEXT Pseudohypoparathyroidism type Ib (PHP-Ib) is a rare disorder resulting from genetic and epigenetic aberrations in the GNAS complex. PHP-Ib, usually defined by renal resistance to parathyroid hormone, is due to a maternal loss of GNAS exon A/B methylation and leads to decreased expression of the stimulatory G protein α (Gsα) in specific tissues. OBJECTIVE To clarify the usefulness of m...

Introduction. Primary hyperparathyroidism (PHP) is characteristically determined by high levels of calcium and high or inappropriate levels of parathyroid hormone (PTH). Technological advances have dramatically changed the surgical technique over the years once intraoperative parathyroid hormone (IOPTH) assay had allowed for focused approaches. Objective. To evaluate our 10-year experience in e...

Primary hyperparathyroidism (PHP) affects 0.5%-1% of the adult population and presents with classical signs of renal lithiasis, cholecystolithiasis, gastrointestinal ulcerations, depression, and osteoporosis. Parathyroid adenoma, hyperplasia and rarely carcinoma are the underlying pathology. Synchronous thyroid and parathyroid pathologies are described in multiple endocrine neoplasia. We report...

Web applications are increasingly popular victims of security attacks. Injection attacks, such as Cross Site Scripting or SQL Injection, are a persistent problem. Even though developers are aware of them, the suggested best practices for protection are error prone: unless all user input is consistently filtered, any application may be vulnerable. When hosting web applications, administrators fa...

The security of the web application bases on the security of the underlying layers, such as OS and application platform layers and the application itself. While the OS layer is beyond control of the PHP project, experience shows that the language is to assist developers in developing more secure code and running it in more secure manner. The majority of the problems in PHP applications is cause...

Primary hyperparathyroidism (PHP) is a known endocrine disorder. Many years ago, the most frequent forms of clinical presentation were symptomatic renal or skeletal disease with moderate or severe hypercalcemia; however, currently, most patients have few symptoms and mild hypercalcemia. The last NIH Workshop on Asymptomatic PHP developed criteria for the management of this disease. Multiple end...

RAP RDF API for PHP is a Semantic Web toolkit for PHP developers. It offers features for parsing, manipulating, storing, querying, serving, and serializing RDF graphs. RAP was started as an open source project by the Freie Universität Berlin in 2002 and has been extended with code contributions from the Semantic Web community. Its latest release (V0.9.1) includes among others: a statement-centr...

This paper presents the architecture and implementation of the EOS 2 failure-masking framework for composite Web Services. EOS 2 is based on the recently proposed notion of interaction contracts (IC), and provides exactly-once execution semantics for general, arbitrarily distributed Web Services in the presence of message losses and component crashes without requiring explicit coding effort by ...