The pathobiology of chronic beryllium disease (CBD) involves the major histocompatibility complex class II human leukocyte antigen (HLA). Although occupational exposure to beryllium is the cause of CBD, molecular epidemiologic studies suggest that specific (Italic)HLA-DPB1(/Italic) alleles may be genetic susceptibility factors. We have studied three-dimensional structural models of HLA-DP prote...

A policy will be used more heavily in a particular time and placewhere its marginal cost is lower. The analyst who treats times and places as identical will overestimate the policy’s net benefit, especially for policy intensities greater than exist in his sample. In regression analysis, the problem can be solved by instrumentalvariables and a correction for heteroskedasticity. In an example usi...

Control of the edge topology of graphene nanostructures is critical to graphene-based electronics. A means of producing atomically smooth zigzag edges using electronic current has recently been demonstrated in experiments [Jia, Science 323, 1701 (2009)10.1126/science.1166862]. We develop a microscopic theory for current-induced edge reconstruction using density functional theory. Our calculatio...

A very curious, valuable, and highly interesting Special Report upon the "Number and Condition of Lunatics and Idiots in Ireland," as presented to Parliament in a General Report on the " Status of Disease" in Ireland, at the period of taking the last census for that country in March, 1851, is now before us. Before proceeding to the more particular object of the Report, it will be instructive to...