نتایج جستجو برای: قدرت هدف ts

تعداد نتایج: 322690  

Journal: :Cancer research 2006
Jonathan R Brody Tomas Hucl Eike Gallmeier Jordan M Winter Scott E Kern Kathleen M Murphy

Thymidylate synthase (TS) is an important target for 5-fluorouracil (5FU)-based therapy. The TS polymorphic 5'-untranslated region tandem repeat sequence is under investigation to guide 5FU treatment, yet current protocols omit consideration of copy number changes at the TS locus. We surveyed the TS tandem repeat sequence and found copy number changes in gastrointestinal cancers. Ten of 12 info...

Journal: :Applied sciences 2021

In this study, a low complexity tabu search (TS) algorithm for multiple-input multiple-output (MIMO) systems is proposed. To reduce the computational of TS algorithm, early neighbor rejection (ENR) and layer ordering schemes are employed. proposed ENR-aided (ENR-TS) least promising k neighbors excluded from set in each layer, which reduces examination iteration. For efficient computation neighb...

2009
Marie-Thérèse Boyer-Xambeu Ghislain Deleplace Patrice Gaubert Lucien Gillard

2010
Yuyan Zhang Shaoli Yang Ming Liu Chunxia Song Ning Wu Peixue Ling Edward Chu Xiukun Lin

Thymidylate synthase (TS), which catalyzes the de novo synthesis of dUMP, is an important target for cancer therapy. In this report, the effects of 5-fluorouracil (5-FU) and ZD1694 on the regulation of TS gene expression were evaluated in zebrafish embryos. Our results revealed that the expression of TS was increased by about six-fold when embryos were treated with 1.0 microM 5-FU and there was...

A Shalizar Jalali G Najafi H Soleimani, M Behfar

Background: Auto-immunization was proposed as the mechanism of contralateral testicular damage following unilateral vas deferens injuries. The objective of this experimental in vitro study was to elucidate the effect of tacrolimus (TS) as a powerful immunosuppressant on contralateral epididymal sperm fertilizing capacity following unilateral vas deferens obstruction (UVO) in mice. Materials and...

Journal: :nephro-urology monthly 0
bahar rostami water and electrolytes research center, isfahan university of medical sciences, isfahan, ir iran mehdi nematbakhsh water and electrolytes research center, isfahan university of medical sciences, isfahan, ir iran; department of physiology, isfahan university of medical sciences, isfahan, ir iran; institute of basic and applied sciences research, isfahan, ir iran; water and electrolytes research center, isfahan university of medical sciences, isfahan, ir iran. tel: +98-9131104751, fax: +98-3137922419 zahra pezeshki water and electrolytes research center, isfahan university of medical sciences, isfahan, ir iran ardeshir talebi water and electrolytes research center, isfahan university of medical sciences, isfahan, ir iran; department of clinical pathology, isfahan university of medical sciences, isfahan, ir iran mohammad reza sharifi department of physiology, isfahan university of medical sciences, isfahan, ir iran fatemeh moslemi water and electrolytes research center, isfahan university of medical sciences, isfahan, ir iran

conclusions it seems that testosterone in low dose, i.e. physiologic dose, protects kidneys against cp-induced nephrotoxicity; however, special care is needed in cp therapy of patients with high levels of ts. results cp increased the serum levels of blood urea nitrogen (bun), creatinine (cr), and malondialdehyde (smda) as well as kidney weight (kw), bodyweight (bw) loss, and kidney tissue damag...

Journal: :The Journal of pharmacology and experimental therapeutics 2011
C Di Cresce R Figueredo P J Ferguson M D Vincent J Koropatnick

Thymidylate synthase (TS) is the only de novo source of thymidylate (dTMP) for DNA synthesis and repair. Drugs targeting TS protein are a mainstay in cancer treatment, but off-target effects and toxicity limit their use. Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and...

Journal: : 2022

هدف: هدف این پژوهش مقایسه اثربخشی امیددرمانی و معنویت درمانی بر کیفیت زندگی، قند خون فشار زنان میانسال مبتلا به دیابت نوع دو بود. روش: حاضر نیمه آزمایشی با طرح پیش آزمون- پس پیگیری گروه گواه جامعه آماری شامل تمام 2 مراجعه کننده مرکز تحقیقات دیابت، متابولیسم غدد شهر تهران در سال 1399 بودند که ‏45 نفر شیوه نمونه‌گیری دسترس انتخاب صورت تصادفی آزمایش یک (هر 15 نفر) قرار گرفتند. ابزار پرسشنامه کوتاه...

Journal: : 2022

هدف: این پژوهش با هدف تحلیل روان­سنجی نسخة کوتاه مقیاس پرطاقتی روانی برای نوجوانان (مک‌گیوئن، کلیر ـ تامپسون و پوتوین، 2016) در بین گروهی از تیزهوش ایرانی انجام شد. روش: همبستگی، 300 نوجوان (150 پسر 150 دختر) به پرسشنامة نظم‌بخشی شناختی هیجان (گارنفسکی، کرایج اسپینهاون، 2001) پاسخ دادند. به‌منظور تعیین روایی عاملی روش­ آماری عامل تأییدی بررسی همسانی درونی ضرایب آلفای کرونباخ استفاده همچنین، مطا...

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