Emergence of artemisinin resistance in Cambodia highlights the importance of characterizing resistance to this class of drugs. Previously, intermediate levels of resistance in Plasmodium falciparum were generated in vitro for artelinic acid (AL) and artemisinin (QHS). Here we expanded on earlier selection efforts to produce levels of clinically relevant concentrations, and the resulting lines w...

Although vaccination campaigns have significantly reduced the number of measles cases worldwide, endemic transmission of measles virus (MV) continues to occur in several continents, including Europe. To obtain current information on measles incidence and molecular data on circulating MVs in Germany, a nationwide measles sentinel was established. Phylogenetic analysis based on the variable part ...

We consider non-supersymmetric p-brane solutions of type II string theories characterized by three parameters. When the charge parameter vanishes and one of the other two takes a specific value, the corresponding chargeless solutions can be regular and describe “bubbles” in static (unstable) equilibrium when lifted to d = 11. In appropriate coordinates, they represent D6 branes with a tubular t...

The antiplasmodial activities of sixty norcantharidin analogs were tested in vitro against a chloroquine sensitive (D6, Sierra Leone) and chloroquine resistant (W2) strains of Plasmodium falciparum. Forty analogs returned IC(50) values <500 μM against at least one of the P. falciparum strains examined. The ring open compound 24 ((1S,4R)-3-(allylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic...

We construct four kinds of 1/4 BPS solutions in massive IIA supergravity corresponding to D8-D0-F1, D8-D2, D8-D4 and D8-D6-NS5 systems. They include many known solutions as special cases. D8-D2 and D8-D4 solutions are represented by harmonic functions as usual, while the other two by solutions of non-linear differential equations. Because these four solutions can be argued in almost identical w...