نتایج جستجو برای: فناوری rnai

تعداد نتایج: 29292  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی اصفهان - دانشکده برق و کامپیوتر 1391

یکی از مراحل رایج در تحقیقات و آزمایش های پزشکی استفاده از روش های مدرن تصویربرداری است. در برخی از این روش ها مانند فرایند rnai که اخیراً مورد توجه محققان قرارگرفته است, تعداد تصاویری که در یک آزمایش تولید می شود بسیار زیاد است. در برخی دیگر مانند استفاده از ریزآرایه ها علاوه بر تعداد زیاد تصاویر تولید شده, ابعاد تصویری که در هر آزمایش تولید می شود نیز بزرگ است .در گروهی دیگر مانند ماموگرافی, ب...

Journal: :Development 2013
Tetsuya Bando Yoshiyasu Ishimaru Takuro Kida Yoshimasa Hamada Yuji Matsuoka Taro Nakamura Hideyo Ohuchi Sumihare Noji Taro Mito

In the cricket Gryllus bimaculatus, missing distal parts of the amputated leg are regenerated from the blastema, a population of dedifferentiated proliferating cells that forms at the distal tip of the leg stump. To identify molecules involved in blastema formation, comparative transcriptome analysis was performed between regenerating and normal unamputated legs. Components of JAK/STAT signalli...

Journal: :Chemistry & biology 2010
Yujing Li Chuan He Peng Jin

RNA interference (RNAi) is a well-conserved mechanism that uses small noncoding RNAs to silence gene expression posttranscriptionally. Gene regulation by RNAi is now recognized as one of the major regulatory pathways in eukaryotic cells. Although the main components of the RNAi/miRNA pathway have been identified, the molecular mechanisms regulating the activity of the RNAi/miRNA pathway have on...

2015
Benjamin Haley Benjamin J. Haley

xii CHAPTER I: INTRODUCTION Overview and history of RNAi Transcriptional silencing: mechanisms and phylogeny Small RNAs and translational repression Self-regulation of small RNA-mediated pathways Small RNA biogenesis RNAi effector proteins RNA-silencing pathway functions RNAi and disease Concerns regarding RNAi-based therapy CHAPTER II: ATP REQUIREMENTS AND SMALL INTERFERING RNA STRUCTURE IN TH...

Journal: :Differentiation; research in biological diversity 2004
Asako Sugimoto

The phenomenon of RNA-mediated interference (RNAi) was first discovered in the nematode Caenorhabditis elegans, in which introduction of double-stranded RNA causes specific inactivation of genes with corresponding sequences. Technical advances in RNAi methodology and the availability of the complete genome sequence have enabled the high-throughput, genome-wide RNAi analysis of this organism. Se...

2010
Lon-Fye Lye Katherine Owens Huafang Shi Silvane M. F. Murta Ana Carolina Vieira Salvatore J. Turco Christian Tschudi Elisabetta Ullu Stephen M. Beverley

RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including many pathogens. While some Leishmania lack RNAi activity and Argonaute or Dicer genes, we show that Leishmania braziliensis and other species within the Leishmania subgenus Viannia elaborate active RNAi machinery. Strong attenuation of expre...

Journal: :Plant physiology 2003
Magdalena Bezanilla Aihong Pan Ralph S Quatrano

The moss Physcomitrella patens performs efficient homologous recombination, which allows for the study of individual gene function by generating gene disruptions. Yet, if the gene of study is essential, gene disruptions cannot be isolated in the predominantly haploid P. patens. Additionally, disruption of a gene does not always generate observable phenotypes due to redundant functions from rela...

2015
Isabel Weinheimer Yaming Jiu Minna-Liisa Rajamäki Olli Matilainen Jukka Kallijärvi Wilmer J. Cuellar Rui Lu Mart Saarma Carina I. Holmberg Jussi Jäntti Jari P. T. Valkonen

Certain RNA and DNA viruses that infect plants, insects, fish or poikilothermic animals encode Class 1 RNaseIII endoribonuclease-like proteins. dsRNA-specific endoribonuclease activity of the RNaseIII of rock bream iridovirus infecting fish and Sweet potato chlorotic stunt crinivirus (SPCSV) infecting plants has been shown. Suppression of the host antiviral RNA interference (RNAi) pathway has b...

2013
Katlin B. Massirer Amy E. Pasquinelli

A recent study by Massirer et al. in the nematode C. elegans has shown that a family of microRNAs (miRNAs), miR-35-41, regulates the efficiency of RNA interference (RNAi), revealing a new connection between these small RNA pathways. In this commentary, we discuss the potential mechanisms for cross regulation in the miRNA and RNAi pathways and the implications for gene expression. While miRNAs a...

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