Elongation factor-2 kinase (eEF-2K) negatively regulates mRNA translation via the phosphorylation and inactivation of elongation factor-2 (eEF-2). We have shown previously that purified eEF-2K can be phosphorylated in vitro by cAMP-dependent protein kinase (PKA) and that this induces significant Ca(2+)/calmodulin (CaM)-independent eEF-2K activity [Redpath and Proud (1993) Biochem. J. 293, 31-34...

Let V be a 2n-dimensional vector space over a field F and Ω be a non-degenerate symplectic form on V . Denote by Hk(Ω) the set of all 2k-dimensional subspaces U ⊂ V such that the restriction Ω|U is non-degenerate. Our main result (Theorem 1) says that if n 6= 2k and max(k, n−k) ≥ 5 then any bijective transformation of Hk(Ω) preserving the class of base subsets is induced by a semi-symplectic au...

Let $G$ be a finite abelian group. The Davenport constant $\mathsf{D}(G)$ is the maximal length of minimal zero-sum sequences over $G$. For groups form $C_2^{r-1} \oplus C_{2k}$ known for $r\leq 5$. In this paper, we get precise value $\mathsf{D}(C_2^{5} C_{2k})$ $k\geq 149$. It also worth pointing out that our result can imply $\mathsf{D}(C_2^{4} C_{2k})$.

In this paper we show that the center of partition algebra $\mathcal{A}_{2k}(\delta)$, in semisimple case, is given by subalgebra supersymmetric polynomials normalised Jucys-Murphy elements. For non-semisimple such a shown to be central, and particular it large enough recognise block structure $\mathcal{A}_{2k}(\delta)$. This allows one give an alternative description for when two simple $\math...

A 321-k-gon-avoiding permutation π avoids 321 and the following four patterns: k(k + 2)(k + 3) · · · (2k − 1)1(2k)23 · · · (k − 1)(k + 1), k(k + 2)(k + 3) · · · (2k − 1)(2k)12 · · · (k − 1)(k + 1), (k + 1)(k + 2)(k + 3) · · · (2k − 1)1(2k)23 · · · k, (k + 1)(k + 2)(k + 3) · · · (2k − 1)(2k)123 · · · k. The 321-4-gon-avoiding permutations were introduced and studied by Billey and Warrington [BW]...

A number of elongation factor-2 kinase (eEF-2K) mutants were constructed to investigate features of this kinase that may be important in its activity. Typical protein kinases possess a highly conserved lysine residue in subdomain II which follows the GXGXXG motif of subdomain I. Mutation of two lysine residues, K340 and K346, which follow the GXGXXG motif in eEF-2K had no effect on activity, sh...

We review the construction and theoretical implications of the USp(2k) matrix model in zero dimension introduced in ref. 1), . It is argued that the model provides a constructive approach to TypeI superstrings and is at the same time dynamical theory of spacetime points. Three subjects are discussed : semiclassical pictures and series of degenerate perturbative vacua associated with the worldvo...

Renal artery stenosis is increasing in prevalence. Angioplasty plus stenting has not proven to be better than medical management. There has been a reluctance to use available denervation methodologies in this condition. We studied conscious, chronically instrumented, two-kidney, one-clip (2K-1C) Goldblatt rats, a model of renovascular hypertension, to test the hypothesis that renal denervation ...