Death due to scorpion envenoming syndrome is a common event in tropical and subtropical countries. Severe scorpion envenoming causes autonomic storm, massive release of catecholamines, counter-regulatory hormones, suppressed insulin/hyperinsulinemia, acute myocarditis, hyperglycemia, increased free fatty Acid levels, acute pancreatitis, disseminated intra-vascular coagulation, acute pulmonary o...

Scorpion mono[‘2sIJiodotoxin binds to a single class of receptor sites associated with voltage-sensitive sodium channels in synaptic nerve ending particles (synaptosomes) with a KD of approximately 3 11~. Scorpion toxin binding is inhibited by depolarization of the synaptosomes with K+ or gramicidin or by lysis of the synaptosomes. Scorpion toxin binding is enhanced by batrachotoxin, veratridin...

OBJECTIVES The aims of this study were to highlight some epidemiological aspects of scorpion envenomations, to analyse and interpret the available data for Biskra province, Algeria, and to develop a forecasting model for scorpion sting cases in Biskra province, which records the highest number of scorpion stings in Algeria. METHODS In addition to analysing the epidemiological profile of scorp...

Death due to scorpion stings is a common event in many countries. Scorpion envenoming syndrome consists of the clinical presentation of pain at the site of sting, nausea, vomiting, sialorrhea, profuse sweating, abdominal pain, tremors, arrhythmias, hypertension, agitation, hyperglycemia, restlessness, prostration, priapism, pulmonary oedema, many other manifestations and may concern the CNS, th...

BACKGROUND Scorpion sting is a common medical emergency in Iran. The epidemiological features and control of such cases vary from south to north. This review will provide new information about the epidemiology of scorpion stings in different provinces of Iran. METHODS In this descriptive retrospective study, data on scorpionism including incidence rates, mortality as well as locality from 200...

The management of scorpion stings, especially those including antivenom treatment, remains a subject of controversy. The purpose of this study was to offer the epidemiologic and clinical characteristics of patients with scorpion sting and to determine the efficacy of antivenom treatment in the management of these patients. A total of 106 adult patients admitted for scorpion sting to our ED betw...

Depolarization of neuroblastoma cells causes a 70-fold increase in the apparent dissociation constant KD for scorpion toxin enhancement of activation of the action potential Na+ ionophore by veratridine and a large increase in the rate of reversal of scorpion toxin action. Depolarization also inhibits binding of 125I-labeled scorpion toxin to a small number of saturable binding sites on electri...

Scorpion stings are a public health problem in south and southwest Iran. There is little information regarding climatological effects on incidence of scorpion stings in Iran. Therefore, the present systemic survey of scorpion sting data was conducted from the point of view of entomo-meteorological relationships and analyzed statistically for the Dezful area in Khuzestan, southwest of Iran. The ...

Purified scorpion toxin (Leiurus quinquestriatus) slows inactivation of sodium channels in frog muscle at concentrations in the range of 17-170 nM. Mono[125I]iodo scorpion toxin binds to a single class of sites in frog sartorius muscle with a dissociation constant of 14 nM and a binding capacity of 13 fmol/mg wet weight. Specific binding is inhibited more than 90% by 3 microM sea anemone toxin ...