This is a medically oriented, multi-authored volume, dealing with candidiasis as a disease, with little emphasis on the microbiology of candida itself. Thus, the specifically mycologic chapter (by Roy L. Hopfer) emphasizes laboratory diagnosis and species differentiation rather than basic metabolism, genetics, and so on, and the experimental section (extensively researched and referenced by Don...

BACKGROUND Vulvovaginal candidiasis is characterized by curd-like vaginal discharge and itching, and is associated with considerable health and economic costs. MATERIALS AND METHODS We examined the incidence, prevalence, and risk factors for vulvovaginal candidiasis among a cohort of 898 women in south India. Participants completed three study visits over six months, comprised of a structured...

The diagnosis of gastro-oesophageal candidiasis by brush cytology was studied in two groups. In eight immunosuppressed patients clinically suspected to have candidiasis, fungal infection was confirmed on six occasions, and a diagnosis of herpetic oesophagitis was established in the other two cases. Among 482 gastric and oesophageal brushings clinically unsuspected candidiasis was found on a fur...

The commensal fungus Candida albicans causes mucosal candidiasis in the rapidly expanding number of immunocompromised patients. Mucosal candidiasis includes oropharyngeal, esophageal, gastrointestinal, and vaginal infections. Vulvovaginal candidiasis (VVC) and antimycotic-refractory recurrent VVC is a frequent problem in healthy childbearing women. Both these mucosal infections can affect the q...

Germ-free BALB/c mice, genetically engineered to be deficient for interleukin-8 (IL-8) receptor homolog (IL-8Rh-/-), were more susceptible to gastric candidiasis after oral challenge and to acute systemic candidiasis after intravenous challenge than IL-8Rh+/+ controls. In comparison to IL-8Rh+/+ mice, the IL-8Rh-/- mice had slower influx of polymorphonuclear neutrophils (PMN) into Candida albic...

UNLABELLED Candidiasis is relatively frequent in neonatal and pediatric intensive care units (ICUs), particularly in preterm infants less than 28 weeks of gestational age. Neonatal candidiasis shows high mortality and is often associated to poor neurodevelopmental prognosis in survivor patients. Amphotericin B and fluconazole are the first choice drugs for the treatment of neonatal candidiasis....

Submit Manuscript | http://medcraveonline.com Abbreviations: AMI: Antibody Mediated Immunity; PMNL: Polymorphonuclear Leucocytes; CMI: Cell-Mediated Immunity; : Chronic Mucocutaneous Candidiasis; GI: Gastrointestinal; NK: Natural Killer; GM-CSF: Granulocyte-Macrophage Colony Stimulating Factor; MPC: Mononuclear Phagocytic Cells; PRPs: Pattern Recognition Receptors; VVC: Vulvovaginal Candidiasis...

In contrast to immunocompetent controls, interleukin-10 (IL-10) knockout (KO) mice eliminated an experimental intravenous inoculation with Candida albicans from their kidneys. Improved clearance of C. albicans from the kidneys of IL-10 KO mice was evident at 24 h after intravenous challenge with the fungus. Conversely, mice with a deletion of the IL-4 cytokine gene were more susceptible to syst...

INTRODUCTION Candidiasis or oral candidiasis is the most frequent mucocutaneous mycosis of the oral cavity. It is produced by the genus Candida, which is found in the oral cavity of 53% of the general population as a common commensal organism. One hundred and fifty species have been isolated in the oral cavity, and 80% of the isolates correspond to Candida albicans, which can colonize the oral ...