BACKGROUND AND PURPOSE Cerebral hypoxic ischemia (HI) is an important cause of brain injury in the newborn infant. Adenosine is believed to protect against HI brain damage. However, the roles of the different adenosine receptors are unclear, particularly in young animals. We examined the role of adenosine A2A receptors (A2AR) using 7-day-old A2A knockout (A2AR(-/-)) mice in a model of HI. MET...

A heat-intolerance (HI) syndrome in cattle in Tanzania was suspected to be associated with previous, clinical foot-and-mouth disease (FMD). A participatory appraisal (PA) method called "matrix scoring" was used to explore livestock-keeper perceptions of association between HI and cattle diseases. A PA method called 'proportional piling' was used to estimate herd incidence of FMD and other disea...

We present the results of high velocity (1.3 km s channels) and high spatial (∼5, or ∼ 250 pc at the distance of I Zw 18) resolution HI synthesis observations of the blue compact dwarf galaxy I Zw 18 to investigate the link between its unique evolutionary history and the neutral gas distribution and kinematics. The HI distribution is extensive, with diffuse neutral gas extending to the northwes...

We present the results of high velocity (1.3 km s channels) and high spatial (∼5, or ∼ 250 pc at the distance of I Zw 18) resolution HI synthesis observations of the blue compact dwarf galaxy I Zw 18 to investigate the link between its unique evolutionary history and the neutral gas distribution and kinematics. The HI distribution is extensive, with diffuse neutral gas extending to the northwes...

We have analyzed the total HI contents of 72 Hickson compact groups of galaxies (HCGs) and the detailed spatial distributions and kinematics of HI within a subset of 16 groups using the high angular resolution observations obtained with the VLA in order to investigate a possible evolutionary scenario for these densest systems in the present day galaxy hierarchy. For the more homogeneous subsamp...

Clinical management of neonatal hypoxic-ischemic encephalopathy (HIE) suffers from the lack of reliable surrogate marker tests. Proteomic analysis may identify such biomarkers in blood, but there has been no proof-of-principle evidence to support this approach. Here we performed in-gel trypsin digestion of plasma proteins from four groups of 10-d-old mice [untouched and 24 h after low-dose lipo...