Reference has been made to the observation that mutations and other sudden bi'ologic changes occur in the untreated descendants of mice that in each of several generations have been given a single subcutaneous injection of methylcholanthrene.'0 It has been suggested that some of these changes can be explained by point mutations while others must have involved a greater biologic alteration. An a...

A new understanding of the notion of regularizer is proposed. It is argued that this new notion is more realistic than the old one and better fits the practical computational needs. An example of the regularizer in the new sense is given. A method for constructing regularizers in the new sense is proposed and justified.