Objective. Gestational Trophoblastic Disease (GTD) management requires clear guidelines for diagnosis, treatment, and follow-up. Unequal management skills among practitioners, inadequate treatment, irregular surveillance, and drop-out are common in resource-limited settings and can lead to life-threatening complications and morbidities. To address these challenges, we implemented a GTD Manageme...

Rab GTPases recruit myosin motors to endocytic compartments, which in turn are required for their motility. However, no Ypt/Rab GTPase has been shown to regulate the motility of exocytic compartments. In yeast, the Ypt31/32 functional pair is required for the formation of trans-Golgi vesicles. The myosin V motor Myo2 attaches to these vesicles through its globular-tail domain (GTD) and mediates...

Gestational trophoblastic disease is a spectrum of placental disorders ranging from benign molar pregnancies to the neoplastic conditions such as invasive mole and choriocarcinoma. These patients are identified early due to markedly elevated hCG levels and characteristic ultrasound findings. Uterine evacuation is the recommended treatment, while chemotherapy can be reserved for patients with re...

BACKGROUND Although the morphological features characteristic of products of conception specimens including molar pregnancies are well described, substantial histopathological similarities are observed between the different entities, especially in cases of early pregnancies. Furthermore, there are no current solid criteria that could predict cases with progression to persistent gestational trop...

Measurement of hCG remains today central for diagnosis, treatment and follow-up of gestational trophoblastic diseases (GTD). In order to evaluate this contribution, we conducted a prospective cohort study in the Service of high-risk pregnancy of Rabat Maternity Les Orangers and the Laboratory of Rabat Military Teaching Hospital Mohammed V over a period of eighteen months. 35 patients were inclu...

A generalisation of the Gaussian doubly dirty multiple access channel to a Gaussian triply dirty multiple access channel (GTD-MAC) is considered, where there are three additive interference signals, each one non-causally known to only associated transmitter. Same as in the Gaussian doubly dirty multiple access channel, Costa’s strategy (i.e. random binning scheme) cannot achieve positive rates ...

AIMS To assess the expression profile of the activated form of signal transducer and activator of transcription (Stat)3 in gestational trophoblastic disease (GTD) and correlate the findings with clinicopathological parameters. METHODS AND RESULTS By immunohistochemistry, both cytoplasmic and nuclear expression of p-Stat3-Ser(727) was demonstrated in 88 trophoblastic tissues, including placent...

Diffraction phenomena studied in electromagnetism, acoustics, and elastodynamics are often modeled using integrals, such as the well-known Sommerfeld integral. The far field asymptotic evaluation of such integrals obtained using the method of steepest descent leads to the classical Geometrical Theory of Diffraction (GTD). It is well known that the method of steepest descent is inapplicable when...

The geometrical theory of diffraction (GTD) provides a powerful and computationally efficient framework for investigating real-world diffraction problems. Originally restricted to perfectly electrically conducting (PEC) wedges, the GTD and its uniform offspring have since been extended to wedges characterized by impedance surfaces (R. Tiberio et al., IEEE Trans. AP, 37, 2, 212-218, 1989). Thoug...

The geometrical theory of diffraction (GTD) as formulated by R. G. Kouyoumjian has been applied to predict the radiation characteristics of hyperboloidal subreflectors with laterally defocused feeds. In caustic or multicaustic directions the scattered fields are. determined AZIMUTH ANGLE Fig. 7. Smoothed theoretical and measured radiation patterns of pyramidal horn reflector antenna with blinde...