Placental development requires extensive angiogenesis and the invasion of the maternal decidua by the trophoblasts. Adequate and organized interaction of vascular endothelial growth factors (VEGF), placenta growth factors (PlGF), and their receptors are essential for a normal development and function of the placenta. In this study, we evaluated the expressions of PlGFs and their receptors, mRNA...

Hypertensive disorders complicating pregnancy are common and form great triad along with hemorrhage and infection. They are one of the important causes resulting in maternal and fetal morbidity and mortality. Metabolic syndrome is a combination of medical disorders that, when occurs together, it increases the risk of developing cardiovascular disease and diabetes. In order to know the risk of d...

OBJECTIVE We longitudinally examined the changes of brachial to ankle distensibility using pulse wave velocity (PWV) throughout pregnancy and its difference between normal pregnancy and pregnancy-induced hypertension (PIH) groups. STUDY DESIGN One hundred and eighty-three pregnant women were included in this study. The PWV examinations were performed in a longitudinal way during the first, se...

Icariin has previously been demonstrated to attenuate hyperglycemia‑induced renal injury, however the renoprotective effects of icariin in a rat model of pregnancy‑induced hypertension (PIH) remain to be elucidated. The present study aimed to investigate the effect of icariin on PIH‑induced acute kidney injury (AKI) and proteinuria. Following 18 days of icariin treatment between day 1 and day 1...

OBJECTIVE Early detection of changes in cardiovascular echocardiographic systolic parameters and their comparison with normotensives women. METHODS This was a hospital-based prospective case-control study carried out in Department of Obstetrics and Gynaecology in S.M.S Medical College, Jaipur, during the period from February 2013 to December 2014. In total, 100 women were enrolled in the stud...

OBJECTIVE To investigate the relationship between some thrombophilic parameters and pregnancy induced hypertension (PIH). METHODS The study took place at the Department of Obstetrics and Gynecology, Perinatology Unit, Faculty of Medicine, Cukurova University, Turkey, between January 2002 and December 2002. We evaluated 202 patients. Patients were divided into 2 groups: control group comprised...

To the Editor: Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis, which occurs after inflammation, trauma, or therapeutic interventions. PIH presents as irregular darkly pigmented macules that can persist for months or even years. PIH occurs more frequently in the darker Fitzpatrick skin types IV to VI, for instance, found in individuals from Africa, Asia, and South America...

Hypertensive disorders complicate about 6 8.0 % of all pregnancies. Currently there is no predictive test for this condition and no cure other than the delivery of the baby. Incidence of pregnancy induced hypertension (PIH) in our study was 14.4%, with maximum cases of emergency admission (83.9%), low socioeconomic group (83.6%), illiterate (57.4%) and who had not taken any antenatal care (61.7...

Iron is a critical nutrient for DNA synthesis and cellular proliferation. Targeting iron in cancer cells using specific chelators is a potential new strategy for the development of novel anticancer agents. One such chelator, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT), possesses potent and selective anticancer activity (J Med Chem 50:3716-3729, 2007). To elucidate the mechanisms of it...

BACKGROUND It is well known that smoking and pregnancy induced hypertension (PIH) are associated with decreased fetal growth. It has been reported that in preeclampsia the fetal growth deficit attributable to smoking is higher, which has been contradicted in other studies. We therefore evaluated the effects on fetal growth of early- and late onset PIH and chronic hypertension and how cigarette ...