amphiphilic cationic micelles have recently attracted much attention as non-viral vector. in the current study the retinoic acid-g-chitosan (ra-chitosan) micelles have been used as novel gene carriers. uptake of micelles, condensation ability and transfection efficiency of micelle–dna complexes (miceplexes) in the presence or absence of serum had been investigated on hela and hepg2 cell lines. ...

2,6-Pyridinediylbisalkanamides were synthesized, using diaminopyridine (DAP) as a linker and alkyl chains of varying lengths, that upon self-assembly form submicron-sized sheets and their uptake into the cytoplasm of HeLa cells was studied by confocal microscopy.

it has been reported that latex and extracts of different species of ficus are cytotoxic to some human cancerous cell lines. in this study, cytotoxicity of fruit and leaf extracts as well as the latex of ficus carica l. on hela cell line were evaluated. ethanolic extracts of leaves and fruits were prepared through percolation and ethyl acetate and dichloromethane extracts were prepared by reflu...

background and objective: in addition to the use of chemicals in food, pharmaceutical, cosmetic and hygiene industries, use of herbal and natural compounds have also increased. it seems natural ingredients compared with the chemical components show less side effects, such as mutagenicity and carcinogenesis however, their use can also be associated with side effects and toxicity. some significan...

Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.

Three antioxidant isoflavonoids characterized as 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3) were isolated from the cultured broth of Streptomyces sp. OH-1049. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. In in vitro studies, these antibiotics were found to possess antioxidant activity w...

A new antibiotic sohbumycin, was isolated from the culture broth of Streptomyces sp. No. 82-85. It appeared to belong to the peptide lactone type of antibiotics from physico-chemical studies and has an empirical formula of C31H47N8O10Cl. In in vitro studies, the antibiotic was found to possess potent cytocidal activity against HeLa S3 cells and antimicrobial activities against Gram-positive bac...

background: mentha species are widely used in traditional medicine mostly as anti-flatulence. nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. moreover, cytotoxic effects of some mentha species have been reported. objective: in this study, cytotoxic properties of mentha piperita, m. spicata, m. aquatica, m. crispa, m. pulegium ...