Ras GTPases include the isoforms H-Ras, K-Ras, and N-Ras. Despite their great biochemical and biological similarities, evidence is mounting suggesting that Ras proteins may not be functionally redundant. A widespread strategy for studying small GTPases is the utilization of dominant inhibitory mutants that specifically block the activation of their respective wild-type proteins. As such, H-Ras ...

R-Ras promotes cell adhesion and activation of integrins through a process that is yet unknown. We show here that active R-Ras (38V) promotes the formation of focal adhesions and a spread cell shape. By contrast, the dominant-negative mutant of R-Ras (43N) reduces the number of focal adhesions, leading to the formation of refractile cells. In adherent cells wild-type R-Ras, activated (38V) R-Ra...

background: domestic and industrial wastewaters are mostly treated by biological process such as activated sludge, aerobic pond, and anaerobic treatment. this study focuses on characterizing the quality of sewage sludge in the sultanate of oman chosen from three industrial sewage treatment plants (stps): rusayl industrial estate (rsl.ie); sohar industrial estate (sie); and raysut industrial est...

در این تحقیق به مقایسه تحلیلی و عددی آبشار جریان برگشتی مدل R با آبشارهای Q QI سیستم‌­های چندجزیی پایدار پرداخته می‌­شود. راستا برای اولین بار کدهای جهت طراحی منظور کد نرم‌افزار متلب نوشته شده‌­اند. نتایج نشان می‌­دهد که دو جزء 1k 2k از خوراک Nc جزء، تعداد معدودی قابل تعریف است همگی حالات خاصی می­‌باشد. هم‌­چنین یافته‌­ها مجموع مقدار برش جزیی همیشه برابر یک است. طریق داده می‌­شود صورتی میانگین ...

The use of reclaimed asphalt pavement (RAP) and/or recycled shingles (RAS) in the mixtures is a common practice U.S.A. However, there controversy to date on how RAP/RAS interact with virgin binders (VABs) mixtures. For containing RAP/RAS, aged RAP and air-blown RAS alter performances extracted (EABs). Thus, rheological properties EABs from these require more investigation. focus this paper was ...

The recirculating aquaculture system (RAS) is a cultivation that minimizes water changes and can optimize high stocking densities (SD). purpose of this study was to determine the effect nursery culture in density with RAS on survival rate (SR), specific growth (SGR), relative length (LR), weight gain (WG), (LG)and feed utility efficiency (FUE) juvenile catfish. used completely randomized design...

The role of three major Ras downstream effector pathways in the induction of mammary cancer was studied using an in situ mammary ductal gene delivery model. Replication-defective retroviral vectors were used to infect endogenous rat mammary epithelial cells with three individual Ras effector loop mutants, each of which transduces its signal through a different Ras effector pathway (Raf, PI3K or...