Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance. Defining circuitry controlling these traits opens new opportunities for chemical diversity in therapeutics, as the cognate inhibitors are rarely explored by conventional screening approaches. This has great potential to address the pressing ...

1. Tracer Kinetic Modeling • Extracellular agents (such as Gd-DTPA) accumulate in the interstitium of many tissues (e.g. muscle) but do not cross the healthy blood-brain-barrier. • Functional information may be obtained by treating Gd-DTPA as a tracer and following its kinetics (as opposed to the conventional ‘static’ approach, inject wait – image once). • After intravenous administration (norm...

OBJECTIVE To determine the utility of intercellular adhesion molecule (ICAM)-1 antibody-conjugated gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA-anti-ICAM-1) as a targeted contrast agent for the molecular magnetic resonance imaging (MRI) in collagen-induced arthritis (CIA). MATERIALS AND METHODS THREE GROUPS OF MICE WERE USED: non-arthritic normal, CIA mice in both the early inflamma...

BACKGROUND Clearance of inhaled technetium-labeled diethylenetriamine pentaacetate (99mTc-DTPA) is a marker of epithelial damage and an index of lung epithelial permeability. The aim of this study was to investigate the role of 99mTc-DTPA scan in patients with Idiopathic Pulmonary Fibrosis (IPF). Our hypothesis is that the rate of pulmonary 99mTc-DTPA clearance could be associated with extent o...

OBJECTIVE To assess the reported rate of local reactions after administration of acellular pertussis vaccine (DTPa) according to dose number and type of pertussis vaccine (whole-cell or acellular) used for the primary course, and to document the severity and outcome of fourth-dose local reactions. DESIGN AND SETTING Retrospective review. Reports of adverse events after vaccination in South Au...

The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by incorporating the targeting peptide cysteine-arginine-glutamic acid-lysine-alanin...

abstract in order to assess the availability of phosphorous (p), different methods have been proposed in the last decades. the results of these methods in soils with various ph, calcium carbonate, organic matter, al and fe oxides and hydroxides and other properties especially in iranian soils can not be used. in addition, knowledge about transformation of p forms is necessary for perception of ...

Recombinant anti‑epidermal growth factor receptor‑internalizing arginine‑glycine‑aspartic acid (anti‑EGFR single‑domain antibody fused with iRGD peptide) protein efficiently targets the EGFR extracellular domain and integrin αvβ/β5, and shows a high penetration into cells. Thus, this protein may improve penetration of conjugated drugs into the deep zone of gastric cancer multicellular 3D sphero...

This report summarises national passive surveillance data collated in the Adverse Drug Reactions Advisory Committee (ADRAC) database at 30 September 2006 for adverse events following immunisation (AEFI) reported for children aged less than 7 years who received vaccines between 1 January and 30 June 2006.1–3 It is the fi rst full reporting period for AEFI data following the introduction of a new...