The goal of metabolomics data pre-processing is to eliminate systematic variation, such that biologically-related metabolite signatures are detected by statistical pattern recognition. Although several methods have been developed to tackle the issue of batch-to-batch variation, each method has its advantages and disadvantages. In this study, we used a reference sample as a normalization standar...

BACKGROUND For a commercially feasible microalgal triglyceride (TAG) production, high TAG productivities are required. The operational strategy affects TAG productivity but a systematic comparison between different strategies is lacking. For this, physiological responses of Nannochloropsis sp. to nitrogen (N) starvation and N-rich medium replenishment were studied in lab-scale batch and repeate...

The appearance of counterfeit medicines in supply chains is a global public health problem that may seriously affect patients. Counterfeit drugs do not meet quality standards and do not declare their real composition and/or source for the purposes of fraud. They may be generic or innovative, they may contain genuine constituents in a fake packaging, or wrong ingredients, or inactive ingredients...

In this article, the control of particle size distribution (PSD) is discussed as a means for the inferential control of the rheology of emulsion polymers. A controllability assessment is presented through a consideration of the process mechanisms to illustrate the attainability or otherwise of bimodal PSD. The suitability of a batch-to-batch iterative feedback PSD control is demonstrated, which...

in this article several control schemes for a pilot scale polymerization reactor are proposed and one of them is selected as the most suitable design. the performances of proposed schemes have been compared through computer simulations. the controllers are pid and chosen reaction is polymerization of methyl methacrylate which is highly exothermic.

the batch fermentation production of human growth hormone (hgh) was studied in a newrecombinant escherichia coli. the effect of different levels of dissolved oxygen and glucoseconcentration on cell density and substrate utilization were evaluated. the results indicated that theoptimum level of dissolved oxygen was 25% of air saturation. the specific growth rate reached amaximum for an optimal g...