Gallium maltolate, tris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium (GaM), is an orally active gallium compound for therapeutic use. It is moderately soluble in water (10.7 +/- 0.9 mg/mL at 25 composite functionC) with an octanol partition coefficient of 0.41+/-0.08. The molecule is electrically neutral in aqueous solution at neutral pH; a dilute aqueous solution (2.5 x10-(-5) M) showed little ...

Satellite-based PM2.5 concentration estimation is growing as a popular solution to map the PM2.5 spatial distribution due to the insufficiency of ground-based monitoring stations. However, those applications usually suffer from the simple hypothesis that the influencing factors are linearly correlated with PM2.5 concentrations, though non-linear mechanisms indeed exist in their interactions. Ta...

Mu bacteriophage inserts its DNA into the genome of host bacteria and is used as a model for DNA transposition events in other systems. The eukaryotic Ku protein has key roles in DNA repair and in certain transposition events. Here we show that the Gam protein of phage Mu is conserved in bacteria, has sequence homology with both subunits of Ku, and has the potential to adopt a similar architect...

In this paper we present the design, implementation, and performance analysis of Group-Aided Multicast (GAM), a scalable many-tomany reliable multicast transport protocol. GAM achieves high quality ACK trees while keeping the tree maintenance overhead reasonably low in the presence of dynamic group membership and route changes. It is supported by a group configuration mechanism organizing the m...

Chondroitin sulfate (CS) glycosaminoglycans inhibit regeneration in the adult central nervous system (CNS). We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation. The CS-boun...

Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA. To counteract the latter activity, bacteriophage λ encodes a small protein inhibitor called Gam that binds to RecBCD and inactivates the comple...

Pervasive Developmental Disorder (PDD) is a categorical term used to classify disorders in which the patient suffers deficits in three main domains: language, behavior and social skills. Heparin Binding Growth Associated Molecule (HB-GAM) is an extracellular protein involved in neurite outgrowth and radial migration. Mice deficient in HB-GAM demonstrate deficits in cognition, behavior and socia...

Quadrature amplitude modulation (QAM), deployed in billions of communication devises, exhibits a shaping-loss of πe/6 (≈ 1.53 dB) compared to the Shannon-Hartley theorem. With inspiration gained from special (leaf, flower petal, and seed) packing arrangements (so called spiral phyllotaxis) found among plants, we have designed a shape-versatile, circular symmetric, modulation scheme, the Golden ...

A generalized additive model (GAM) of blue shark, Prionace glauca, catch rates (catch per set) was ®tted to data gathered by National Marine Fisheries Service (NMFS) observers stationed aboard Hawaii-based commercial longline vessels (N ˆ 2010 longline sets) from March 1994 to December 1997. Its coef®cients were then applied to the values of predictor variables, which were also contained in log...

Generalized Additive Models (GAM) are a widely popular class of regression models to forecast electricity demand, due to their high accuracy, flexibility and interpretability. However, the residuals of the fitted GAM are typically heteroscedastic and leptokurtic caused by the nature of energy data. In this paper we propose a novel approach to estimate the time-varying conditional variance of th...