Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, and decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme in mitochondrial FAO, is higher in human adipose tissue macrophages than in adipocytes and that it is differentially expr...

It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffected. Efforts to pharmacologically inhibit FAO more than 90% revealed that high...

Asthmatic patients with fixed airway obstruction (FAO) and patients with chronic obstructive pulmonary disease (COPD) share similarities in terms of irreversible pulmonary function impairment. Exhaled nitric oxide (eNO) has been documented as a marker of airway inflammation in asthma, but not in COPD. To examine whether the basal eNO level and the change after exercise may differentiate asthmat...

2 The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations (FAO) or of the World Health Organization (WHO) concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers ...

The Programme Against African Trypanosomiasis30 Information System (PAAT-IS) is hosted by FAO and it produces, collates, stores, analyses, and disseminates information on tsetse, trypanosomiasis and related sustainable agriculture and rural development for the benefit of 37 trypanosomiasis affected countries of sub-Saharan Africa and of international FAO/PAAT partners. In 2006 PAAT-IS began to ...

The incidence of obesity and insulin resistance is growing, and the increase in type 2 diabetes mellitus (DM2) constitutes one of the biggest challenges for our healthcare systems. Many theories are proposed for the induction of insulin resistance in glucose and lipid metabolism and its metabolic sequelae. One of these mechanisms is lipotoxicity (1–4): excess lipid supply and subsequent lipid a...

BACKGROUND Ingesting Yerba Maté (YM) has become widely popular for health promotion, obesity prevention and body weight reduction, primarily due its thermogenic effectiveness. However, the YM effects on fat metabolism during exercise, when fat metabolism is already increased several fold, are unknown. The present study investigated whether acute YM ingestion augments fat metabolism parameters o...

The Programme Against African Trypanosomiasis1 Information System (PAAT-IS) is hosted by FAO and it produces, collates, stores, analyses, and disseminates information on tsetse, trypanosomiasis and related sustainable agriculture and rural development for the benefit of 37 trypanosomiasis affected countries of sub-Saharan Africa and of international FAO/PAAT partners. In 2006 PAAT-IS began to u...

This document has been prepared at the request of the Secretariat of the FAO Commission on Genetic Resources for Food and Agriculture, and in close collaboration with the FAO Plant Production and Protection Division, to facilitate the Commission’s deliberations when it will review key issues on targets and indicators for plant genetic resources for food and agriculture at its Fifteenth Regular ...

BACKGROUND We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an inherent component. The purpose of the current study was to determine if an impairment in whole-body fatty acid oxidation (FAO) was also evident in children with a severely obese...