Guggulipid is an extract of the guggul tree Commiphora mukul and has been widely used to treat hyperlipidemia in humans. The plant sterol guggulsterone (GS) is the active agent in this extract. Recent studies have shown that GS can act as an antagonist ligand for farnesoid X receptor (FXR) and decrease expression of bile acid-activated genes. Here we show that GS, although an FXR antagonist in ...

Sir, We read with interest the paper by Keen and colleagues.' The case bears striking similarity to that of a 55 year old Indian man recently treated in our hospital. For 9 months he had taken 2-4 tablets daily of a resin extract from the Balsamodedron mukul plant. Each tablet contained 6.5-7.5 mg of lead as well as recordable levels of mercury and arsenic. This was associated with anaemia, abd...

Achieving QoS for TCP traffic in Satellite Networks with Differentiated Services Arjan Durresi, Sastri Kota, Mukul Goyal, Raj Jain, Venkata Bharani Department of Computer and Information Science, The Ohio State University, 2015 Neil Ave, Columbus, OH 43210-1277, USA Tel: 614-688-5610, Fax: 614-292-2911, Email: {durresi, mukul, bharani}@cis.ohio-state.edu Lockheed Martin 60 East Tasman Avenue MS...

The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Anti...

Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, causes apoptosis in cancer cells but the sequence of events leading to cell death is poorly understood. We now show that guggulsterone-induced cell death in human prostate cancer cells is caused by reactive oxygen intermediate (ROI)–dependent activation of c-Jun NH2-terminal kinase (JNK). Exposure of PC-3 and LNC...

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG ...

Guggulsterone (GS) [4,17(20)-pregnadiene-3,16-dione] is a phytosterol found in the gum resin of the Commiphora mukul. GS exists naturally in two stereoisomers: E-GS (cis-GS) and Z-GS (trans-GS). In this study, the effects of both isomers on expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) were evaluated in human mammary epithelial (MCF10A) cells. NF-E2-related factor 2 (Nrf2) is ...

Bansal, Mukul Subodh, "Algorithms for minimum bipartite fill-in and the gene-duplication problem " (2006). Retrospective Theses and Dissertations. Paper 852.

Knee effusion is an abnormal accumulation of the fluid in the knee capsule or the adjoining supra-patellar bursa secondary to the irritation/inflammation in the joint synovium. It is seen in approximately 8-10 % of the total patients suffering from osteo-arthrosis. Kroṣṭukaśīrṣaas described in Ayurveda, can be corelated with knee effusion. In Present clinical trial an effort has been made to ev...