نتایج جستجو برای: رتروترنسپوزونهای ltr

تعداد نتایج: 3405  

2017
Rosa Maria Cossu Claudio Casola Stefania Giacomello Amaryllis Vidalis Douglas G Scofield Andrea Zuccolo

The accumulation and removal of transposable elements (TEs) is a major driver of genome size evolution in eukaryotes. In plants, long terminal repeat (LTR) retrotransposons (LTR-RTs) represent the majority of TEs and form most of the nuclear DNA in large genomes. Unequal recombination (UR) between LTRs leads to removal of intervening sequence and formation of solo-LTRs. UR is a major mechanism ...

Journal: :Journal of virology 1997
L Zhang Y Huang H Yuan B K Chen J Ip D D Ho

Human immunodeficiency virus type 1 (HIV-1)-infected individuals who remain asymptomatic despite prolonged infection present a unique opportunity to understand virologic and immunologic factors involved in the pathogenesis of AIDS. We have previously identified a group of long-term survivors (LTS) who are clinically healthy and immunologically normal despite 13 to 15 years of HIV-1 infection. I...

Journal: :International Journal of Bioscience, Biochemistry and Bioinformatics 2015

نعناع از جمله گیاهان بسیار مهم دارویی است که مصارف گسترده ای در صنایع دارویی و غذایی دارد. گونه Mentha piperita L از خانواده نعناعیان (Labiatae) ازدو منطقه: یکی شهرستان کرج،...

Journal: :Journal of virology 2004
Aaron C Logan Dennis L Haas Tal Kafri Donald B Kohn

To make human immunodeficiency virus type 1 (HIV-1)-based vectors safer for use in the research and clinical setting, a significant modification to the HIV-1 genome has been the deletion of promoter and enhancer elements from the U3 region of the long terminal repeat (LTR). Vectors containing this deletion are thought to have no LTR-directed transcription and are called self-inactivating (SIN) ...

Journal: :Journal of virology 1994
P Olson S Nelson R Dornburg

Self-inactivating (SIN) retroviral vectors contain a deletion spanning most of the right long terminal repeat's (LTR's) U3 region. Reverse transcription copies this deletion to both LTRs. As a result, there is no transcription from the 5' LTR, preventing further replication. Many previously developed SIN vectors, however, had reduced titers or were genetically unstable. Earlier, we reported tha...

2015
Slava Rom Nancy L. Reichenbach Holly Dykstra Yuri Persidsky

Multifactorial mechanisms comprising countless cellular factors and virus-encoded transactivators regulate the transcription of HIV-1 (HIV). Since poly(ADP-ribose) polymerase 1 (PARP-1) regulates numerous genes through its interaction with various transcription factors, inhibition of PARP-1 has surfaced recently as a powerful anti-inflammatory tool. We suggest a novel tactic to diminish HIV rep...

Journal: :Nucleic acids research 1987
F Harada N Tsukada N Kato

Three kinds of human endogenous retrovirus-like sequences (HuERS-P1, 2 and 3) were isolated from a HeLa cell genomic library using the 3'-half fragment of proline tRNA as a hybridization probe. These elements contained putative primer binding sites complementary to the 3'-terminus of proline tRNA and long terminal repeats (LTRs) characteristic of retrovirus provirus. The LTR sequence of HuERS-P...

Journal: :Nucleic acids research 1986
A Feenstra J Fewell K Lueders E Kuff

We studied the relation between LTR methylation and expression of the family of endogenous retrovirus-like elements related to mouse intracisternal A-particles (IAP). Comparative HpaII/MspI and HhaI restriction analysis of genomic DNA's showed that in cells and tissues with a low level of IAP gene expression, HpaII and HhaI sites within the 5' LTR were heavily methylated, while in cells abundan...

2016
Di Qu Chuan Li Feng Sang Qiang Li Zhi-Qiang Jiang Li-Ran Xu Hui-Jun Guo Chiyu Zhang Jian-Hua Wang

The 5' end of HIV-1 long terminal repeat (LTR) serves as a promoter that plays an essential role in driving viral gene transcription. Manipulation of HIV-1 LTR provides a potential therapeutic strategy for suppressing viral gene expression or excising integrated provirus. Subtype-specific genetic diversity in the LTR region has been observed. The minor variance of LTR, particularly in the trans...

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