نتایج جستجو برای: دیگوکسین digoxin

تعداد نتایج: 3205  

Journal: :Polish journal of pharmacology 2004
Fatma S Kilic Ozlem Batu Başar Sirmagul Engin Yildirim Kevser Erol

It is known that digoxin, which is a liposoluble cardiac glycoside, is well absorbed from intestine. In the present study, the absorption rates of digoxin from rat duodenum and the proximal and terminal parts of small intestine were determined in vitro. The isolated everted duodenum and intestinal sacs were put into oxygenated Tyrode solution at 37 degrees C. The Tyrode solution on the outer, m...

Journal: :American heart journal 1986
J J Lynch D G Montgomery B R Lucchesi

The proarrhythmic potential of digoxin, administered in a therapeutic dosage regimen, was evaluated in conscious dogs in the subacute phase of myocardial infarction. In this evaluation, digoxin (0.0125 mg/kg/day intravenously) or vehicle were administered to conscious dogs for periods of 5 to 7 days, commencing 4 to 5 days after anterior myocardial infarction. Before treatment, programmed ventr...

2005
Robert E. Kleiger Donald C. Harrison

The influence of potassium deficiency on myocardial H-digoxin concentration in the mouse was studied. Tritiated digoxin, 400 /Ag/kg, was injected intraperitoneally into mice, which were killed at varying time intervals, and the "H-digoxin was extracted. One-half of the mice were made potassium deficient by a diet free of potassium. In control animals, myocardial H-digoxin was maximal by 30 min ...

Journal: :Clinical chemistry 1985
M H Gault L Longerich M Dawe S C Vasdev

This method for assaying digoxin in serum with improved specificity combines small-column extraction of serum, "high-performance" liquid chromatography, and RIA of the eluted fractions. Analytical recoveries of 1.0, 0.5, and 0.1 microgram/L standards were 95%, 93%, and 84%, respectively. The CVs for duplicates and replicates of sera with values of 0.5 to 1 microgram/L were 4 to 6%. Fifty-nine s...

Journal: :Circulation research 1967
K E Cohn R E Kleiger D C Harrison

The influence of potassium deficiency on myocardial H-digoxin concentration in the mouse was studied. Tritiated digoxin, 400 /Ag/kg, was injected intraperitoneally into mice, which were killed at varying time intervals, and the "H-digoxin was extracted. One-half of the mice were made potassium deficient by a diet free of potassium. In control animals, myocardial H-digoxin was maximal by 30 min ...

Journal: :Eurasian journal of toxicology 2021

Digoxin is a drug commonly used to achieve rate control in heart failure and atrial fibrillation with some form of arrhythmia. It shows positive inotropic effect by inhibiting the Na + / K ATPase pump myocardial cell membrane. Since digoxin narrow therapeutic range, dose range should be monitored individual regimen established, taking care plasma concentrations. Factors such as patient's age, r...

ژورنال: :مجله دانشکده پرستاری و مامایی همدان 0
دکتر فاطمه زراعتی f. zeraati, ph.d. دکتر محسن قراخانی m. gharakhani, m.d. دکتر ابراهیم نادی e. nadi, m.d. دکتر ملیحه عراقچیان m. araghchian, pharm.d. m.j. asari, m.sc. m.h. farjoo, ph.d. m. fallah, ph.d.

زمینه و هدف : گلیکوزیدهای قلبی از داروهای قدیمی در درمان نارسایی قلب می باشند و امروزه دیگوکسین که از اعضای این گروه است کاربرد بالینی وسیعی دارد. به دلیل کوچک بودن ایندکس درمانی ، کوچکترین تغییر در خصوصیات کینتیکی دارو می تواند سطح سرمی سمی از دارو ایجاد کند. هدف از این تحقیق بررسی سطح سرمی دیگوکسین در بیماران بستری دربیمارستان اکباتان همدان در سال1384بود. روش کار: این تحقیق یک پژوهش توصیفی ـ ...

2002
Amitava Dasgupta

Endogenous digoxin-like immunoreactive substance (DLIS) was first reported in volumeexpanded dogs. Its presence has been confirmed in blood, urine, and other body fluids. Elevated DLIS concentrations are encountered in patients with volume-expanded conditions such as uremia, essential hypertension, liver disease, and preeclampsia. DLISs cross-react with antidigoxin antibodies and falsely elevat...

Journal: :iranian journal of medical sciences 0
m.h. nemati m. eskandari

background: atrial fibrillation (af) is one of the most common arrhythmias after coronary artery bypass graft (cabg) surgery. af can result in hemodynamic instability, thromboembolic events, increase the perioperative myocardial infarction, congestive heart failure, stroke, more length of hospital stay (lohs) and cost of treatment. the aim of this study was to evaluate the independent effect of...

2010
Simon Lowes Iain S. Haslam Britt-Marie Fihn Constanze Hilgendorf Johan E. Karlsson Nicholas L. Simmons Anna-Lena Ungell

The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed. After intravenous or oral digoxin dosing the arterial and hepatic portal vein (oral) AUC(0-24h) were significantly reduced by PCN pre-treatment. Biliary digoxin clearance increased 2-fold following PCN treatment. PCN signif...

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