In recent years, oxygen targeting has become a relevant topic in neonatal intensive care medicine.1 Despite large SpO2 targeting trials including numerous subjects and the available results of a meta-analysis of these data,2,3 there is still an ongoing debate on the optimum SpO2 target range in preterm infants. Both conditions, hyperoxia as well as hypoxia, frequently occur in extremely low bir...

Oxygen therapy is a mainstay of critical care medicine, yet its optimal therapeutic use has not been systematically evaluated. A detailed understanding of current practice in oxygen therapy in intensive care is required to enable future interventional studies. We aimed to describe current oxygenation practice in patients requiring ≥48 hours of mechanical ventilation (MV) at an academic tertiary...

We determined the effects of chronic exposure to intermittent hypoxia (CIH) on chemoreflex control of ventilation in conscious animals. Adult male Sprague-Dawley rats were exposed to CIH [nadir oxygen saturation (SpO2), 75%; 15 events/h; 10 h/day] or normoxia (NORM) for 21 days. We assessed the following responses to acute, graded hypoxia before and after exposures: ventilation (V̇e, via baromet...

Results Mean PaO2/FiO2 at baseline was 200 ± 57 mm Hg in the HFNC group and 205 ± 59 mm Hg in the BVM group (p = 0.76). Mean SpO2 at baseline was 96 ± 3 % in the HFNC group and 94 ± 4 % in the BVM group (p = 0.24). The mean lowest oxygen saturation measured by pulse oximetry (SpO2) during intubation was 89 ± 18 % in the HFNC group and 86 ± 11 % in the BVM group (p = 0.56). During the one minute...

BACKGROUND Managing the oxygen saturation of preterm infants to a target range has been the standard of care for a decade. Changes in target ranges have been shown to significantly impact mortality and morbidity. Selecting and implementing the optimal target range are complicated not only by issues of training, but also the realities of staffing levels and demands. The potential for automatic c...

BACKGROUND AND PURPOSE This investigation identified ventilation distribution, gas mixing, lung function, and arterial blood oxyhemoglobin saturation (SpO2) physiologic responses to 2 independent airway clearance treatments, high-frequency chest wall oscillation (HFCWO) and low positive expiratory pressure (PEP) breathing, for subjects who had cystic fibrosis (CF) and who were hospitalized duri...

BACKGROUND The study was aimed to explore the association between arterial oxygen saturation (SpO2) and spirometer parameters of disease severity in chronic obstructive pulmonary disease (COPD) patients with a view to identify whether the pulse oximetry can be used as an alternative to arterial values in the clinical management of COPD patients in a routine practice. MATERIALS AND METHODS Thi...

We have assessed the influence of different surgical procedures on the incidence, severity and duration of early postoperative hypoxaemia in 312 healthy infants and children undergoing elective palatoplasty. Group 1 patients underwent von Langenbeck palatoplasty (n = 149), group 2 patients underwent push-back palatoplasty (n = 124) and group 3 patients underwent combined push-back palatoplasty ...