Software developers often encapsulate reusable code as Application Programming Interfaces (APIs). The co-evolution of applications and APIs may motivate an API migration: the replacement of application dependencies to an original API by dependencies to an alternative API that provides similar functionality and abstractions. In this dissertation, we investigate issues associated with API migrati...

Electronic Health Records (EHR) offer patients the opportunity to access their own medical records. Google and Microsoft recently extended their public services by introducing internet-based personal healthcare information platforms – Google Health and Microsoft HealthVault. Over one hundred thousand people have registered at the two services since they were launched. Both companies invite othe...

We present the OWL API, a high level Application Programming Interface (API) for working with OWL ontologies. The OWL API is closely aligned with the OWL 2 structural specification. It supports parsing and rendering in the syntaxes defined in the W3C specification (Functional Syntax, RDF/XML, OWL/XML and the Manchester OWL Syntax); manipulation of ontological structures; and the use of reasonin...

Software developers often need to port applications written for a source platform to a target platform. One of the key tasks here is to find matching API calls in the target platform for the given API calls in the source platform. This task involves exhaustive reading in target platform API (Application Programming Interface) documentation to identify API methods corresponding to the given API ...

Api SI and Api SII are serine proteases of the honeybee venom containing allergenic determinants. Each protease consists of two structural modules: an N-terminal CUB (Api SI) or a clip domain (Api SII) and a C-terminal serine protease-like (SPL) domain. Both domains are connected with a linker peptide. The knowledge about the structure and function of Api SI and Api SII is limited mainly to the...

Flavonoids are polyphenolic compounds that are ubiquitous in plants and have biological effects on cancer cells and other cell types. In particular, apigenin (API) has been shown to bind to estrogen receptors, which affect the development, maturation, function, and plasticity of the nervous system. The aim of this study was to investigate the effects of 4?,5,7trihydroxyflavone (API) upon the ne...