The efficacy of percutaneous transluminal angioplasty (PTA) is usually expressed as the angiographic result. Access flow (Qa) measurements offer a means to quantify the functional effects. This study was performed to evaluate the short-term functional and angiographic effects of PTA and to determine the longevity of the functional effects during the follow-up period. Patients with an arterioven...

Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD). We have previously shown that the KP is over activated in AD brain and that QA accumulates in amyloid plaques and within dystrophic neurons. We hypothesized that QA in pathophysiolo...

Immunological and biochemical characteristics of the Qa-2 murine nonclassical histocompatibility class 1 antigen expressed on tumor cells derived from H-2k (Qa-2-) mice were studied. It was found that the Qa-2 antigen on normal H-2b lymphocytes reacted with Qa-2-specific monoclonal antibodies (mAbs) 34-1.2, 59 (both specific to the alpha 1/alpha 2 region) and 141-15.8 (specific to the alpha 3 d...

Quinolinic acid (QA) is an N-methyl-d-aspartate agonist that has been shown to produce neurotoxic effects that mimic certain neurodegenerative diseases when administered to laboratory animals. Intrastriatal injections of QA in rats have been used extensively to produce some of the neuropathological and behavioral deficits that are analogous to Huntington's disease (HD). However, acute intrastri...

This paper describes the participation of QA@LF, the question-answering system from LF/INESC-ID, at the QA track of CLEF in 2008. Making intensive use of a Natural Language Processing chain (which includes, among others, a morphological analyzer, a disambiguation module, a multi-word recognizer, a chunker and a named entities recognizer), QA@LF is based on a three module approach to answer ques...

In this paper, we show that we can obtain a good baseline performance for Question Answering (QA) by using only 4 simple features. Using these features, we contrast two approaches used for a Maximum Entropy based QA system. We view the QA problem as a classification problem and as a reranking problem. Our results indicate that the QA system viewed as a reranker clearly outperforms the QA system...