نتایج جستجو برای: تحلیل تطبیقی قوسگیری شده dca

تعداد نتایج: 555175  

2009
Li Bian Elisabet Josefsson Ing-Marie Jonsson Margareta Verdrengh Claes Ohlsson Maria Bokarewa Andrej Tarkowski Mattias Magnusson

INTRODUCTION Dichloroacetate (DCA) has been in clinical use for the treatment of lactacidosis and inherited mitochondrial disorders. It has potent anti-tumor effects both in vivo and in vitro, facilitating apoptosis and inhibiting proliferation. The pro-apoptotic and anti-proliferative properties of DCA prompted us to investigate the effects of this compound in arthritis. METHODS In the prese...

2011
Peter W. Stacpoole

BACKGROUND Dichloroacetate (DCA) is known to environmental scientists as a by-product of water chlorination and as a metabolite of industrial solvents, including Superfund chemicals. In contrast, DCA is studied by clinical investigators for its therapeutic potential in several life-threatening conditions, including genetic mitochondrial diseases, pulmonary arterial hypertension, and cancer. Thu...

Journal: :Evolutionary Intelligence 2008

Journal: :Crystals 2021

The synthesis and structural characterization of six dicyanamido-cadmium(II) complexes are reported: catena-[Cd(μ1,3-dca)(μ1,5-dca)(3-ampy)] (1), catena-[Cd3(μ1,3,5-dca)2(μ1,5-dca)4(pyNO)2(H2O)2] (2), catena-{Cd(H2O)2(μ1,5-dca)2](2,6-lut-NO)} (3), catena-[Cd(Me2en)(μ1,5-dca)2] (4), catena-[Cd(Me4en)(μ1,5-dca)2] (5), [Cd(1,8-damnp)2(dca)2] (6), where dca = dicyanamide anion, 3-ampy 3-aminopyridi...

2014
Auri Brackmann Vanderlei Both Elizandra Pivotto Pavanello Rogério de Oliveira Anese Fabio Rodrigo Thewes

Apples (Malus domestica, Borkh.) which are not stored at low temperature or in a properly controlled atmosphere (CA) may have a high metabolic rate during the postharvest stage resulting in losses in quality. The aim of this study was to evaluate the quality of ‘Royal Gala’ apple fruit stored in accordance with a new method of dynamic controlled atmosphere (DCA).The respiratory quotient (RQ) wa...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Sharad Khare Cory Holgren Allen M Samarel

Environmental factors, including dietary fats, are implicated in colonic carcinogenesis. Dietary fats modulate secondary bile acids including deoxycholic acid (DCA) concentrations in the colon, which are thought to contribute to the nutritional-related component of colon cancer risk. Here we demonstrate, for the first time, that DCA differentially regulated the site-specific phosphorylation of ...

Journal: :Gut 1995
H Noshiro K Chijiiwa I Makino K Nakano I Hirota

The relations between the concentration of deoxycholic acid (DCA), the cholesterol saturation index, and the nucleation time in gall bladder bile were measured to determine the role of DCA in bile in the pathogenesis of cholesterol gall stone disease. Bile was obtained from patients with cholesterol gall stones (n = 30), subjects without gall stones (n = 35), and patients with pigment gall ston...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2004
Deborah A Keys Irvin R Schultz Deirdre A Mahle Jeffrey W Fisher

Dichloroacetic acid (DCA), a minor metabolite of trichloroethylene (TCE) and water disinfection byproduct, remains an important risk assessment issue because of its carcinogenic potency. DCA has been shown to inhibit its own metabolism by irreversibly inactivating glutathione transferase zeta (GSTzeta). To better predict internal dosimetry of DCA, a physiologically based pharmacokinetic (PBPK) ...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012
Gianmario Bosticardo Fabio Malberti Carlo Basile Loretta Leardini Pasquale Libutti Oliviero Filiberti Enrico Schillaci Pietro Ravani

BACKGROUND There is no consensus regarding the optimal dialysate calcium concentration (DCa) during haemodialysis (HD). Low DCa may predispose to acute arrhythmias, whereas high DCa increases the long-term risk of soft tissue calcifications. METHODS Twenty-two HD patients treated in four dialysis centres underwent two HD sessions, respectively, with 1.5 and 1.25 mmol/L total DCa. Calcium mass...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2006
Xu Guo Vaishali Dixit Huiping Liu Albert L Shroads George N Henderson Margaret O James Peter W Stacpoole

Dichloroacetate (DCA) is an investigational drug for certain metabolic disorders, a by-product of water chlorination and a metabolite of certain industrial solvents and drugs. DCA is biotransformed to glyoxylate by glutathione S-transferase zeta (GSTz1-1), which is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism. Clinically relevant doses of DCA (mg/kg/day) decrease ...

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