The purpose of this study is to investigate the role of PI3K-Akt signaling in prostate cancer cell growth and androgen receptor (AR)-mediated gene expression. Androgendependent LNCaP cells and their androgen-independent counterpart, LNCaP-AI cells, were used. We found that PI3KAkt signaling is elevated in LNCaP-AI cells compared to that in LNCaP cells and is involved in androgen-independent gro...

Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid ((177)Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, (177)Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and (177)LuCl3. Lu-177 chloride was ...

The 90-kD lung endothelial cell adhesion molecule-1 (Lu-ECAM-1) selectively promotes Ca(2+)-dependent adhesion of lung-metastatic B16 melanoma cells. Corresponding with their metastatic performance, high lung-metastatic B16-F10 melanoma cells bind in significantly higher numbers to Lu-ECAM-1 than their intermediate and low lung-metastatic counterparts B16-L8-F10 and B16-F0, respectively. Maximu...

Mosquito Magnet-X traps were modified for use with blue, green, red, and blue-green-red light-emitting diodes and olfactory attractants to determine the response of Lutzomyia shannoni (Dyar) and Lutzomyia vexator (Coquillett) (Diptera: Psychodidae) field populations to these attractants. Red and blue-green-red-baited traps captured the highest numbers of Lu. shannoni and Lu. vexator, respective...

Lutheran blood group glycoproteins (Lu gps) are receptors for the extracellular matrix protein, laminin. Studies suggest that Lu gps may contribute to vasoocclusion in sickle cell disease and it has recently been shown that sickle cells adhere to laminin isoforms containing the a5 chain (laminin 10/11). Laminin a5 is present in the subendothelium and is also a constituent of bone marrow sinusoi...

LU-111995 is a novel antipsychotic drug in clinical development. It has a clozapine-like receptor profile and affinities for dopamine D(4) and 5-hydroxytryptamine(2A) receptors. The effects of LU-111995 were examined in three models of disrupted prepulse inhibition (PPI) in rats. The first model tested the hypothesis that LU-111995 would normalize the deficit in PPI exhibited by rats treated wi...

The first T(d)-symmetric lutetium metallofullerene, Lu(2)@C(76), has been synthesized, isolated, and characterized. Because of the charge transfer from the encapsulated Lu atoms to the T(d)-C(76) fullerene cage, the otherwise unstable T(d)-C(76) fullerene can be significantly stabilized as a Lu(2)@C(76) fullerene. Both STM and STS results are consistent with a charge state of (Lu(2))(6+)@C(76)(...

The effects of replacing Pr by Lu on the magnetic behaviour and structures of Pr(1-x)Lu(x)Mn(2)Ge(2) (x = 0.2,x = 0.4) have been investigated using x-ray diffraction, Mössbauer spectroscopy, magnetization and neutron diffraction measurements. The substitution of Lu for Pr leads to a decrease in the lattice constants a, c and the unit cell volume V at room temperature with this contraction of th...

Introduction: The Lu-Hf decay system can be used to resolve planetary differentiation timescales, but this application requires knowledge of Hf isotopic evolution for bulk planets. Because Lu and Hf are refractory and lithophile, the isotopic evolution of bulk planets and their silicate portions can be reconstructed by back-calculation from the present-day Hf/Hf and Lu/Hf in chondrites [1–3]. H...