UNLABELLED Spatial and temporal coregistration of nuclear and optical images can enable the fusion of the information from these complementary molecular imaging modalities. A critical challenge is in integrating the optical and nuclear imaging hardware. Flexible fiber-based fluorescence-mediated tomography (FMT) systems provide a viable solution. The various bore sizes of small-animal nuclear i...

OBJECTIVE The aim of this study was to evaluate the impact of fecal donor-unrelated donor mix (FMT-FURM) transplantation as first-line therapy for C. difficile infection (CDI) in intestinal microbiome. METHODS We designed an open, two-arm pilot study with oral vancomycin (250mg every 6 h for 10-14 days) or FMT-FURM as treatments for the first CDI episode in hospitalized adult patients in Hosp...

UNLABELLED An altered intestinal microbiome during chronic human immunodeficiency virus (HIV) infection is associated with mucosal dysfunction, inflammation, and disease progression. We performed a preclinical evaluation of the safety and efficacy of fecal microbiota transplantation (FMT) as a potential therapeutic in HIV-infected individuals. Antiretroviral-treated, chronically simian immunode...

BACKGROUND Fecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear. OBJECTIVE We conducted this systematic review to assess the efficacy and safety of FMT in UC. DATA SOURCES PubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for...

The Flare Monitoring Telescope (FMT) was constructed in 1992 at Hida observatory in Japan to investigate the long-term variation of solar activity and explosive events. It has been part of the international coordinated observations program (STEP) since 1991. The FMT consists of five solar imaging telescopes and one guidescope. The five telescopes SIMULTANEOUSLY observe the full-disk Sun at diff...

OBJECTIVE Proteases are emerging biomarkers of inflammatory diseases. In atherosclerosis, these enzymes are often secreted by inflammatory macrophages, digest the extracellular matrix of the fibrous cap, and destabilize atheromata. Protease function can be monitored with protease activatable imaging probes and quantitated in vivo by fluorescence molecular tomography (FMT). To address 2 major co...

The microbiome is increasingly recognized as an important influence on human health and many of the comorbidities that affect patients after solid organ transplantation (SOT) have been shown to involve changes in gut bacterial populations. Thus, microbiome changes in an individual patient may have important health implications after SOT but this area remains understudied. We describe changes in...

Background. Pseudomembranous enteritis (PME) is an acute inflammatory bowel disease affecting pediatric population. The aim of this study was to discuss the characteristics, diagnosis, and management of pediatric PME, and the potential possibility of fecal microbiota transplantation (FMT) application in pediatric PME. Methods. The clinical manifestations, laboratory testing, diagnosis, and trea...